Collaborative Research: IDBR: The Nanosizer: A New Nanolithographic Tool for Preparing Combinatorial Arrays in Situ

合作研究：IDBR：Nanosizer：一种用于原位制备组合阵列的新型纳米光刻工具

• 批准号: 1152139
• 负责人: Chad Mirkin
• 金额: $ 27.5万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1152139&HistoricalAwards=false
• 关键词: Collaborative; Research; IDBR; Nanosizer; New

The Directorate for Biological Sciences through their Instrument Development for Biological Research program and the Division of Chemistry through Chemical Measurement and Imaging support Prof. Chad A. Mirkin, Northwestern University, and Prof. Adam B. Braunschweig, New York University, to develop a new instrument to fabricate nanoarrays of biologically active probes. This new instrument, termed the Nanosizer, will produce combinatorial arrays of oligonucleotides, oligopeptides, and many other biologically active small molecules with sub-100 nanometer feature diameters over large areas (10's of cm2); thereby achieving order of magnitude improvements in feature size, production rate, and cost over current technologies and providing access to fundamental biological experiments that could not otherwise be undertaken. This goal will be achieved by combining massively-parallel tip based nanolithography strategies with new microfluidic designs, and photochemically activated combinatorial surface syntheses. Following proof-of-concept demonstrations, the instrument will be systematically optimized with regard to chemical kinetics and reaction times and automated to facilitate instrument operation. This interdisciplinary project uniquely combines elements of chemistry, engineering, and materials science to create an instrument capable of producing arbitrary patterns of soft matter over large areas, where the chemical composition and position of every feature can be controlled precisely.The new instrument developed in the context of this collaborative proposal will address a major problem for industrial and academic researchers by providing a facile method for preparing arbitrary nanopatterns of biologically active probes. Moreover, the Directorate of Biological Research will sustain Prof. Mirkin and Prof. Braunschweig's outreach activities, including financial support of summer students from minority-serving four year colleges to assist in this project during the summer and a range of other outreach activities that increase scientific awareness at eminent institutions including the Museum of Science and Industry in Chicago, the Metropolitan Museum of Art in New York, and the Young Women's Leadership School of East Harlem.

生物科学理事会通过其生物研究仪器开发计划以及化学测量和成像化学部支持西北大学的 Chad A. Mirkin 教授和纽约大学的 Adam B. Braunschweig 教授开发一种新的制造生物活性探针纳米阵列的仪器。这种被称为 Nanosizer 的新仪器将产生寡核苷酸、寡肽和许多其他生物活性小分子的组合阵列，这些小分子在大面积（数十平方厘米）上具有亚 100 纳米特征直径；从而与现有技术相比，在特征尺寸、生产率和成本方面实现了数量级的改进，并提供了通过其他方式无法进行的基本生物实验。这一目标将通过将基于大规模并行尖端的纳米光刻策略与新的微流体设计以及光化学激活组合表面合成相结合来实现。在概念验证演示之后，该仪器将在化学动力学和反应时间方面进行系统优化，并实现自动化以促进仪器操作。这个跨学科项目独特地结合了化学、工程和材料科学的元素，创造了一种能够在大面积上产生任意软物质图案的仪器，其中每个特征的化学成分和位置都可以精确控制。该合作提案的背景将通过提供一种简便的方法来制备生物活性探针的任意纳米图案，从而解决工业和学术研究人员面临的一个主要问题。此外，生物研究理事会将支持 Mirkin 教授和 Braunschweig 教授的外展活动，包括为少数族裔四年制大学的暑期学生提供财政支持，以在夏季协助该项目，以及一系列其他外展活动，以提高科学水平芝加哥科学与工业博物馆、纽约大都会艺术博物馆和东哈莱姆青年女性领导力学校等知名机构的关注度很高。