Collaborative Research: Large-Scale Nanomanufacturing of Well-Positioned and Highly Aligned DNA Wires from a Capillary Bridge

合作研究：从毛细管桥大规模纳米制造定位良好且高度对齐的 DNA 线

• 批准号: 1153663
• 负责人: Zhiqun Lin
• 金额: $ 15.24万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1153663&HistoricalAwards=false
• 关键词: Collaborative; Research; Large; Scale; Nanomanufacturing

The research objective of this project is to develop simple yet robust methods for massively producing well-positioned nanostructured materials composed of DNA or DNA-based nanocomposites, which possess unprecedented regularity, over a large area (i.e., large scale). Subsequent functionalization of highly ordered DNA can serve as multifunctional materials for a variety of potential applications in nanoelectronic devices. Three specific research goals will be pursued throughout this proposed project: (1) Produce highly ordered structures of DNA and DNA-based nanocomposites by controlling the flow of an evaporating liquid. (2) Develop a reliable and scalable strategy for integrating individual nanoscale building blocks (i.e., DNA) into functional two-dimensional devices with high density. By performing two consecutive evaporation-induced self-assemblies, it is possible to create highly ordered 2D DNA nanowire arrays. (3) Understand the formation mechanisms of ordered structures. The ability to predict the length scale of periodicity, height, and width and compare them with experimental observations is key to the understanding on the structure formation. This research is transformative in that it seeks to mass produce high-density functional nanodevices and nanocircuits, built upon well-positioned, highly ordered DNA or DNA nanocomposites for use in nanoelectronics, nanotechnology, and biotechnology, thereby transitioning fundamental scientific discoveries into useful technologies. The research project will be integrated with nanoscience and nanoengineering education. The educational efforts include recruitment of female undergraduate students, recruitment of high school teachers and students with an emphasis on minority in summer to perform one week of research, and development of lesson plans on DNA and DNA-based nanocomposites by high-school female interns.

该项目的研究目的是开发简单但可靠的方法，用于大规模生产由DNA或基于DNA的纳米复合材料组成的良好的纳米结构材料，这些纳米复合材料具有前所未有的规律性，在大面积（即大型）上。随后的高度有序DNA的功能化可以用作多功能材料，用于在纳米电子设备中的各种潜在应用。在整个拟议的项目中，将实现三个具体的研究目标：（1）通过控制蒸发液体的流量来产生高度有序的DNA和基于DNA的纳米复合材料的结构。 （2）制定一种可靠且可扩展的策略，以将单个纳米级构件（即DNA）整合到高密度的功能性二维设备中。通过执行两个连续的蒸发诱导的自组件，可以创建高度有序的2D DNA纳米线阵列。 （3）了解有序结构的形成机制。预测周期性，高度和宽度的长度规模并将其与实验观察进行比较的能力是对结构形成的理解的关键。这项研究具有变革性，因为它试图大规模生产高密度的功能性纳米电路和纳米电路，该纳米电路构建基于位置良好，有序高度有序的DNA或DNA纳米复合材料，用于纳米电子学，纳米技术和生物技术，从而将基本科学发现转移到有用的技术中。该研究项目将与纳米科学和纳米工程教育集成。教育工作包括招募女性本科生，招募高中教师和夏季少数群体的学生进行一周的研究，并制定了有关高中女性实习生对DNA和DNA基于DNA的纳米复合材料的制定。