Efficient Reactions - Selective Cu(I) Catalysts

高效反应 - 选择性 Cu(I) 催化剂

• 批准号: 1152020
• 负责人: Mykhailo Shatruk
• 金额: $ 40.5万
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1152020&HistoricalAwards=false
• 关键词: Efficient; Reactions; Selective; Cu; Catalysts

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor D. Tyler McQuade of the Department of Chemistry and Biochemistry at Florida State University will develop new synthetic methods by creating (1) stereoconvergent allylic substitutions, providing the same stereoisomer for both cis and trans substrates; (2) catalyst-controlled reactivity where neighboring stereocenters have limited impact on diastereoselectivity; and (3) regiocontrolled catalytic hydroborations. As rare metals such as rhodium and iridium become more expensive, it is critically important to increase the range of reactions that can be performed by inexpensive metals such as copper. The resulting methods could be more efficient and selective than prior reactions and could enable new strategies to construct valuable complex molecules from less expensive metals, providing the basic science necessary to improve sustainability. The proposed work is predicted to result in not only a more thorough understanding of catalysts that provide greater chemical control but also the creation of promising new synthetic methods. The successful results of this work will positively impact the pharmaceutical, agrochemical and specialty chemical industries. In addition, this project will provide excellent training of students, from undergraduate to post-doctoral, including those from groups historically underrepresented in the sciences. These students will become the vanguard, leading the way into a future of more environmentally-friendly and internationally-competitive organic chemistry.

在化学部化学综合计划资助的该项目中，佛罗里达州立大学化学和生物化学系的D. Tyler McQuade教授将通过（1）立体结合的烯丙基替代来开发新的合成方法，从（2）催化剂控制的反应性，而相邻的立体中心对非对映选择性的影响有限； （3）重新控制的催化液压。随着诸如韵律和鸢尾花等稀有金属变得更加昂贵，因此提高铜等铜等铜色可以执行的反应范围至关重要。与先前的反应相比，最终的方法可能更有效，更有选择性，并且可以使新的策略从廉价金属中构建有价值的复杂分子，从而提供了提高可持续性的必要基础科学。预计拟议的工作不仅会对提供更大的化学控制的催化剂有更彻底的了解，而且还会产生有希望的新合成方法。这项工作的成功结果将对药物，农业和特种化学工业产生积极影响。此外，该项目将为从本科到博士后的学生提供出色的培训，包括科学历史上人数不足的团体的学生。 这些学生将成为先锋队，带领前往更环保和国际竞争性的有机化学的未来。