CAREER: Paper-based surface enhanced Raman spectroscopy (P-SERS) for biosensing using inkjet-fabricated devices

职业：使用喷墨制造设备进行生物传感的纸基表面增强拉曼光谱 (P-SERS)

• 批准号: 1149850
• 负责人: Ian White
• 金额: $ 40万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1149850&HistoricalAwards=false
• 关键词: CAREER; Paper; based; surface; enhanced

The objective of this program is to create a new and transformative class of lateral-flow bioanalytical microsystems based on inkjet fabrication and paper-based surface enhanced Raman spectroscopy (P-SERS) for multi-analyte detection. While paper-based sensors have recently emerged for simplistic assays, the proposed approach of fabricating bio-functionalized surfaces and optofluidic SERS detection elements using inkjet printing enables sensitive and sophisticated assays that are extraordinarily low in cost and simple to perform.The intellectual merit of this effort is the establishment of the fundamental components that enable the emergence of new methodologies in sophisticated paper-based assays. These components include: (i) inkjet-based functionalization of cellulose paper with biomolecules andplasmonic nanostructures, (ii) Raman reporter molecules that are highly reactive with metal nanostructures, and (iii) a quantitative understanding of the mass transport advantages of paper-based fluidic biosensors.The broader impacts of this research are centered around the transformative approach to bioanalytics enabled by the P-SERS paradigm. The incredibly low cost of the proposed P-SERSmicrosystems combined with the unprecedented ease of use will lead to a broad range of new applications that require highly sensitive, low-cost disposable analytical devices, including applications in disaster response, at-home health care, and infectious disease screening. In addition, the unique properties of the P-SERS technology enable it to be incorporated as an educational tool at all stages of learning and in any environment. Research opportunities and engineering design projects built around inkjet fabrication and paper-based analytics will be created for underrepresented high school students and for undergraduate engineering students.

该程序的目的是基于喷墨制造和基于纸张的表面增强的拉曼光谱（P-sers）创建一种新的和变革的侧向流生物分析微型系统，以进行多种分析物检测。虽然最近出现了基于纸张的传感器进行简单的测定，但使用喷墨打印制造生物功能化表面和光氟的检测元件的建议方法可以使敏感和精致的成本较低且易于执行的精致成本较低，并且易于执行的智力优点，这些努力的构造是构成的，这些构成的构造是构成了新的方法。这些成分包括：（i）基于喷墨的纤维素纸与生物分子和质量纳米结构的功能化，（ii）拉曼记者分子，这些分子与金属纳米结构高反应性，以及（iii）对基于纸张的流体生物发音层的构造促进式构成的批量交通优势的定量理解。 p-sers范式。拟议的P-Sersmicrosystems的成本非常低，结合前所未有的易用性将导致广泛的新应用，这些应用需要高度敏感，低成本的可支配分析设备，包括在灾害反应，家庭医疗保健和感染性疾病筛查中的应用。此外，P-SERS技术的独特属性使其能够在学习的各个阶段和任何环境中作为教育工具合并。研究机会和工程设计项目围绕喷墨制造和基于纸张的分析，将为代表性不足的高中学生和本科工程专业的学生创建。