Collaborative Research: Directed Charge Transfer in Metal Containing Peptide Nucleic Acid Assemblies

合作研究：含金属肽核酸组装体中的定向电荷转移

• 批准号: 1057953
• 负责人: David Beratan
• 金额: $ 39万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1057953&HistoricalAwards=false
• 关键词: Collaborative; Research; Directed; Charge; Transfer

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Catalina Achim of Carnegie Mellon University, David Waldeck of University of Pittsburgh, and David Beratan of Duke University will develop hybrid inorganic-nucleic acid structures and study charge transfer through these structures with the goal to direct and control charge flow on length scales up to tens of nanometers. Peptide nucleic acid (PNA) building blocks that contain electroactive units will be used, together with complementary nucleic acids (DNA or PNA) as a template for the building blocks, to self-assemble and form preprogrammed electroactive assemblies. The key feature of the proposed research is the general and modular approach to incorporate inorganic or organic charge transfer components at predefined spatial locations in a nucleic acid-based structural scaffold. The team of researchers with complementary expertise (synthesis, characterization, and theory) will collaborate to define the synthetic methodologies, to develop the predictive models, and to quantify the structure and the function of these novel electroactive, supramolecular structures. The broader impacts of this collaborative research program originate from: (1) the creation of new paradigms for charge transfer, (2) the creation of new pedagogical tools for science education that make use of cyber-infrastructure, and (3) outreach activities that enhance diversity in the STEM workforce. This work will enhance our fundamental understanding of charge transfer in nano-size, supramolecular structures that mimic similar-size structures present in biological systems. Ultimately such work could lead to a general approach for integrating electronic platforms with biological systems.

在这个项目中，化学部的大分子，超分子和纳米化学计划，卡内基·梅隆大学的卡塔利娜·阿奇姆，匹兹堡大学的戴维·沃尔德克以及杜克大学的戴维·贝拉塔坦将开发出与这些结构的范围内的混合核酸结构和研究，并将量子与范围进行指向转移，并控制范围内的范围，并控制量子的范围，并控制了量子的范围。将使用包含电活性单元的肽核酸（PNA）的构建块，并将互补的核酸（DNA或PNA）作为构建块的模板，以自组装并形成预编程的电动组件。拟议的研究的关键特征是在基于核酸的结构支架中，在预定义的空间位置纳入无机或有机电荷转移成分的通用和模块化方法。具有互补专业知识（综合，表征和理论）的研究人员团队将合作定义合成方法，开发预测模型，并量化这些新型电活性，超分子结构的结构和功能。该协作研究计划的更广泛影响源于：（1）创建用于收费转移的新范式，（2）创建用于利用网络基础设施的科学教育的新教学工具，以及（3）增强STEM劳动力多样性的外展活动。这项工作将增强我们对纳米大小的超分子结构中的电荷转移的基本理解，这些结构模仿了生物系统中存在的相似大小的结构。 最终，这样的工作可能会导致将电子平台与生物系统集成的一般方法。