CAREER: Microfluidic 3D Apoptosis Cell Arrays

职业：微流控 3D 凋亡细胞阵列

• 批准号: 1055608
• 负责人: Sihong Wang
• 金额: $ 40万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1055608&HistoricalAwards=false
• 关键词: CAREER; Microfluidic; 3D; Apoptosis; Cell

This CAREER award will lead to the development of a high-throughput functional microfluidic platform and unique cellular constructs such that dynamic readouts of signaling associated with cell death pathways such as apoptosis can be investigated. The work combines advances in engineering such as BioMEMS with current knowledge in molecular and cell biology and pharmacology. This platform will be used to examine the mechanism of action of anticancer drugs, and ultimately be used in rapid drug screening. The research will lead to a reduction in time to development of new drugs, not just for cancer, but potentially for a variety of diseases.The educational goals of this award, to enhance research opportunities and increase the number of students from underrepresented groups entering the professional workforce of biotechnology and bioengineering, will be achieved by (i) offering summer research experiences to high school students; (ii) increasing the retention of undergraduate engineering students; (iii) reaching out to industry to promote recruitment of biomedical engineering (BME) graduates; and (iv) enhancing the BME students' competitiveness in the job market of biotech/bioengineering by incorporating up-to-date biotechnologies into the CCNY BME curriculum and providing undergraduate research opportunities. For high school students, the research experiences will build their scientific knowledge and encourage them to pursue the BME major.

该职业奖将促进高通量功能微流体平台和独特细胞结构的开发，以便可以研究与细胞死亡途径（例如细胞凋亡）相关的信号的动态读数。 这项工作将 BioMEMS 等工程技术的进步与分子和细胞生物学以及药理学的最新知识结合起来。该平台将用于检查抗癌药物的作用机制，并最终用于药物快速筛选。 该研究将缩短新药的开发时间，不仅针对癌症，而且可能针对多种疾病。该奖项的教育目标是增加研究机会并增加来自代表性不足群体的学生数量生物技术和生物工程的专业劳动力，将通过以下方式实现：（i）为高中生提供暑期研究经验； (ii) 提高工程本科生的保留率； (iii) 与业界接触，促进生物医学工程（BME）毕业生的招聘； (iv) 通过将最新的生物技术纳入 CCNY BME 课程并提供本科生研究机会，提高 BME 学生在生物技术/生物工程就业市场的竞争力。对于高中生来说，研究经历将建立他们的科学知识并鼓励他们攻读 BME 专业。