U.S.-Turkey Planning Visit: Collaborative Research on the Development of Biosensors for DNA Mutations Assay, July 2010

美国-土耳其计划访问：DNA 突变检测生物传感器开发合作研究，2010 年 7 月

• 批准号: 1036579
• 负责人: Chenzhong Li
• 金额: $ 1.97万
• 依托单位: Florida International University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1036579&HistoricalAwards=false
• 关键词: U.S.; Turkey; Planning; Visit; Collaborative

Li OISE-1036579This project "US-Turkey Planning Visit: Collaborative Research in the Development of Biosensors for DNA Mutations Assay, July 2010" supports the travel of Dr. Chenzhong, Florida International University and three graduate students to Turkey to meet with Dr. Arzum E. Gursan at Ege University in Izmir and with Dr. Nilgun Batdogan at Istanbul Technical University to gain knowledge of nanomaterial preparation and impedance modeling and to develop a viable plan for a US-Turkey collaborative project to be submitted to NSF and to TUBITAK (NSF counterpart in Turkey). They also plan to visit Koc University in Istanbul to visit its micro-nanotechnologies research center.Intellectual Merits: The merits of the planned research include an improved understanding of DNA mutant detection using a novel magnetic nanoparticle based electrochemical impedance DNA biosensor. This understanding includes detail of the design of the sensing chip, synthesis and functionalization of magnetic nanoparticles, training of electrochemical impedance technique and data modeling. Eventually this understanding will be applied to test the feasibility of developing chip based DNA biosensors. This collaboration will enable the research by sharing complementary expertise and research resources between the two groups and create a project that will address a critical challenge in the field of nanotechnology.Broader Impacts: The visiting team consists of the PI and three graduate students with a spread of expertise and varying levels of experience working on the MEMS/NEMS fabrication and biomedical device testing. The project has the potential to create broader benefits to society with the possible commercialization of the DNA biosensor technology to expand the scope of these efforts beyond fundamental research. One graduate student will be primarily trained on the synthesis and functionalization of magnetic nanoparticles. The other graduate student will focus on the training of electrochemical impedance technique and the data modeling and the third will bring the experiences to the students in Dr. Gursan?s lab in a program specific for device design such as AUTOCAD. The preliminary results obtained will be used for the NSF- TUBITAK proposal. The young researchers will be exposed to state-of the-art facilities in an international setting. Additionally, web-based communication will be on-going after the international experience to foster a continuing relationship between the two group?s students. The project activities will advance new technology development while promoting teaching, training and learning and establishing strong ties between the U.S. and Turkey in biosensor research. This project is co-funded by the Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET) and the Office of International Science and Engineering (OISE).

Li OISE-1036579该项目“美国-土耳其计划访问：DNA突变检测生物传感器开发的合作研究，2010年7月”支持佛罗里达国际大学陈中博士和三名研究生前往土耳其与Arzum博士会面伊兹密尔埃格大学的 E. Gursan 和伊斯坦布尔技术大学的 Nilgun Batdogan 博士一起了解纳米材料制备和阻抗建模的知识，并制定可行的计划美国-土耳其合作项目将提交给 NSF 和 TUBITAK（NSF 土耳其对应机构）。 他们还计划访问伊斯坦布尔的科克大学，参观其微纳米技术研究中心。 智力优点：计划研究的优点包括使用基于新型磁性纳米颗粒的电化学阻抗 DNA 生物传感器提高了对 DNA 突变体检测的理解。这种理解包括传感芯片的设计细节、磁性纳米粒子的合成和功能化、电化学阻抗技术的培训和数据建模。 最终，这种理解将被应用于测试开发基于芯片的 DNA 生物传感器的可行性。此次合作将通过两个小组之间共享互补的专业知识和研究资源来实现研究，并创建一个解决纳米技术领域关键挑战的项目。 更广泛的影响：访问团队由 PI 和三名研究生组成，范围广泛在 MEMS/NEMS 制造和生物医学设备测试方面拥有丰富的专业知识和不同程度的经验。该项目有潜力为社会创造更广泛的利益，DNA 生物传感器技术可能实现商业化，从而将这些努力的范围扩大到基础研究之外。 一名研究生将主要接受磁性纳米粒子的合成和功能化方面的培训。另一名研究生将专注于电化学阻抗技术和数据建模的培训，第三名研究生将在 AUTOCAD 等特定于设备设计的项目中为 Gursan 博士实验室的学生带来经验。获得的初步结果将用于 NSF-TUBITAK 提案。年轻的研究人员将在国际环境中接触最先进的设施。此外，在国际体验结束后，将继续进行基于网络的交流，以促进两组学生之间的持续关系。该项目活动将推动新技术开发，同时促进教学、培训和学习，并在美国和土耳其之间在生物传感器研究方面建立牢固的联系。该项目由化学、生物工程、环境和运输系统部（CBET）和国际科学与工程办公室（OISE）共同资助。