NSF/FDA Scholar-In-Residence at FDA: Program on Small-Scale Medical Devices

NSF/FDA FDA 常驻学者：小型医疗器械项目

基本信息

批准号：
1041375
负责人：
Roger Narayan
金额：
$ 13万
依托单位：
North Carolina State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2010
资助国家：
美国
起止时间：
2010-11-01 至 2013-10-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1041375&HistoricalAwards=false
关键词：
NSF FDA Scholar Residence Program

项目摘要

1041375NarayanConventional ossicular replacement prostheses have demonstrated several problems during clinical use, including migration, puncture of the eardrum, difficulty in shaping the prostheses, and reactivity with the surrounding tissues. Novel materials and prostheses that provide improved sound transmission for longer periods of time are demanded by patients and surgeons. In this work, they hypothesize that two photon polymerization may be used to fabricate ossicular replacement prostheses with patient-specific designs and suitable chemical, biological, mechanical, and functional properties for long-term in vivo use. The quadratic character of the two photon absorption probability and the well-defined polymerization threshold of this system will allow one to overcome the diffraction limit and achieve features as small as 200 nm. Two photon polymerization provides several advantages over conventional techniques for scalable production of ossicular replacement prostheses and other small-scale medical devices. First, the raw materials used in this process are widely available and inexpensive. Second, two photon polymerization can be set up in a conventional clinical environment (e.g., an operating room) that does not contain cleanroom facilities. Third, two photon polymerization of ossicular replacement prostheses is an rapid, straightforward, single-step process, as opposed to conventional multiple-step fabrication techniques.

1041375 NarayanconStrental骨化替代假体在临床使用过程中表现出了几个问题，包括迁移，耳膜穿刺，塑造假体的难度以及与周围组织的反应性。患者和外科医生需要新的材料和假体可改善长时间的声音传播。在这项工作中，他们假设可以使用两种光子聚合来用特定于患者的设计以及合适的化学，生物学，机械和功能特性来造成骨化替代假体，以长期使用。该系统的两个光子吸收概率和明确定义的聚合阈值的二次特征将使一个人能够克服衍射极限并实现高达200 nm的特征。两种光子聚合具有比常规技术的几个优势，用于可扩展的骨化替代假体和其他小规模的医疗设备。首先，此过程中使用的原材料广泛可用且便宜。其次，可以在不包含洁净室设施的传统临床环境（例如手术室）中建立两个光子聚合。第三，与常规的多步制造技术相比，骨化替代假体的两个光子聚合是一个快速，直接，单步的过程。