MRI: Acquisition of a 600 MHz NMR Spectrometer for Research and Teaching Activities at California State University Northridge

MRI：购买 600 MHz NMR 波谱仪用于加州州立大学北岭分校的研究和教学活动

• 批准号: 1040134
• 负责人: Karin Crowhurst
• 金额: $ 77.24万
• 依托单位: The University Corporation, Northridge
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1040134&HistoricalAwards=false
• 关键词: MRI; Acquisition; 600; MHz; NMR

With this award from the Major Research Instrumentation (MRI) program Professor Karin Crowhurst and colleagues Eric Kelson, Paul Shin, Thomas Minehan and Yann Schrodi from California State University Northridge will acquire a 600 MHz nuclear magnetic resonance (NMR) spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas of study such as the investigation of protein dynamics and structure in the neurotrophin and RGS families of signaling proteins; to better understand the mechanisms of signal transmission and regulation; synthesis of C-aryl glycosides to use as nucleoside analogues and for sequence-specific DNA binding; preparation of ruthenium complexes that selectively catalyze inner-sphere hydride transfer to ketones; synthesis of trinuclear group 4 metal complexes to catalyze nitrogen activation/hydrogenation; and design and synthesis of enediyne-based aromatase modulators, a promising class of therapeutics for breast cancer treatment.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists and biochemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.

借助大型研究工具（MRI）计划教授Karin Crowhurst和同事Eric Kelson，Paul Shin，Paul Shin，Thomas Minehan和来自加利福尼亚州立大学Northridge的Yann Schrodi将获得600 MHz的核磁共振（NMR）光谱仪。该提案旨在增强各个级别的研究培训和教育，尤其是在研究领域，例如对信号蛋白的神经营养蛋白和RGS家族的蛋白质动力学和结构进行研究；更好地了解信号传输和调节的机制； C-芳基糖苷的合成用作核苷类似物和序列特异性DNA结合；制剂的弦芬族配合物有选择地催化内球氢化物转移至酮；三核组4金属复合物的合成可催化氮的激活/氢化；以及基于Enediyne的芳香化酶调节剂的设计和合成，这是一种有前途的乳腺癌治疗类型类别。核磁共振（NMR）光谱是化学家可用于阐明分子结构的最强大工具之一。它用于识别未知物质，以表征分子中原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行Frontier研究的化学家和生物化学家来说，获得最先进的NMR光谱仪至关重要。这些NMR研究的结果将对合成有机/无机化学和生物化学产生影响。该工具将是教学和研究的组成部分。