MRI: Aquisition of an EPR Spectrometer

MRI：购买 EPR 波谱仪

基本信息

批准号：
1039845
负责人：
Richard Holz
金额：
$ 22.21万
依托单位：
Loyola University of Chicago
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2010
资助国家：
美国
起止时间：
2010-10-01 至 2013-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1039845&HistoricalAwards=false
关键词：
MRI Aquisition EPR Spectrometer

项目摘要

With this award, co-funded by the Division of Chemistry and the Major Research Instrumentation (MRI) program, Professor Richard Holz from Loyola University of Chicago will acquire an electron paramagnetic resonance spectrometer equipped with low temperature liquid helium capabilities and an X band cavity operational in both perpendicular and parallel modes. The proposal is aimed at enhancing research training and education at all levels, especially in areas of study such as investigations of metallohydrolases and metallohydratases, biologically relevant metal centers, catalytic role of the dinuclear metal binding site in ADP glucose pyrophosphorylase, electronic and catalytic properties of the dinuclear active site of Aminopeptidase P, Mn(II) and divalent VO metal substituted derivatives of alpha subunits of guanine nucleotide binding proteins and copper, zinc superoxide dismutase and applications of X band EPR at low temperatures.An EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid state materials. It may also be used to obtain information about the lifetimes of free radicals, short-lived, highly reactive species involved in valuable chemical transformations as well as the initiation of pathological tumor growth. These studies will impact a number of areas, from the synthesis of inorganic and organic molecules to the development of new solid state materials to compounds of biological interest. Employing examples inspired from ongoing research, this instrument will be an integral part of research and teaching at the undergraduate and graduate levels.

凭借该奖项由化学系和主要研究仪器（MRI）计划共同资助，芝加哥洛约拉大学的理查德·霍尔兹（Richard Holz）教授将获得具有低温液体氦气功能的电子顺磁性共振光谱仪，并且具有低温液体氦气功能和X频段型在垂直模式和平行模式中。该提案旨在增强各个级别的研究培训和教育，尤其是在研究领域，例如对金属水合酶和金属水合酶的研究，生物学相关的金属中心，ADP金属结合位点在ADP葡萄糖葡萄糖酸性层次磷酸酶，电子和催化性的ADP葡萄糖结合位点的催化作用鸟嘌呤核苷酸结合蛋白和铜，锌超氧化物歧化酶的α亚基的衍生物以及在低温下X Band EPR的应用。一个EPR光谱仪得出有关分子和固态材料的几何和电子结构的详细信息。它也可用于获取有关自由基的寿命，短暂的，高反应性的物种，涉及有价值的化学转化以及病理肿瘤生长的启动。这些研究将影响许多领域，从合成无机分子和有机分子到开发新的固态材料到生物学意义的化合物。该乐器采用了正在进行的研究启发的示例，将是本科和研究生级别研究和教学的组成部分。