International Collaboration in Chemistry: Green Chemistry for Catalytic C-C Coupling of Renewable Feedstocks

国际化学合作：可再生原料催化 C-C 偶联的绿色化学

• 批准号: 1021640
• 负责人: Michael Krische
• 金额: $ 35.1万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1021640&HistoricalAwards=false
• 关键词: International; Collaboration; Chemistry; Green; Catalytic

The Chemical Catalysis Program in the Chemistry Division supports Professor Michael J. Krische of the University of Texas- Austin in the US. The international collaborator, Professor Bernhard Breit of Albert-Ludwigs-Universität in Germany is supported by the German funding agency, DFG, in a collaboration that will design new routes to commodity and fine chemicals. The proposal for which this award was granted was submitted in response to Program Announcement NSF 09-608: International Collaboration in Chemistry (ICC) between US investigators and their Counterparts Abroad. The researchers propose to develop catalytic processes that enable byproduct-free manufacture of chemical products from abundant, renewable resources. The Breit Group will design and prepare a series of novel phosphine ligands that incorporate supramolecular recognition elements specifically tailored for the activation of carbonyl groups, including carbon dioxide. These "first-generation metal complexes" will be assayed in C-C bond forming hydrogenations developed by the Krische Group in order to establish key structure-reactivity and structure-selectivity trends that will allow Krische and Breit to design improved second-generation catalysts that will be prepared by the Breit Group and assayed by the Krische Group. The collaboration between the Krische and Breit groups is an ideal combination of scientific expertise that will enhance both groups through direct exposure to research techniques, approaches, philosophies, and networks across the Atlantic. The proposed research intends to achieve the high catalyst activities and selectivities necessary to activate new substrates efficiently on a large scale, which will enhance fine chemical applications, including the manufacture of pharmaceuticals. The largest impact of this proposal will be in education through research. The requested funds are for undergraduate and graduate students, who will benefit from the unique opportunity to acquire skills across the disciplines of synthetic organic chemistry, physical organic chemistry, and transition metal inorganic chemistry. Students from groups historically underrepresented in the sciences will also be recruited to participate. The Krische Group participates in programs such as the "Pfizer Research Fellowship for Under-Represented Minorities" and the NIH sponsored "Bridges to the Future" program, which facilitates the transition of minority students from BS/MS to Ph.D. degree granting institutions. Additionally, Professor Krische has mentored several students using NIH-sponsored "Research Supplements to Promote Diversity in Health-Related Research."

化学部的化学催化项目得到了美国德克萨斯大学奥斯汀分校的 Michael J. Krische 教授的支持，国际合作者、德国阿尔伯特路德维希大学的 Bernhard Breit 教授得到了德国资助机构 DFG 的支持。该项目旨在设计商品和精细化学品的新路线，该提案是为了响应 NSF 09-608 计划公告而提交的：美国之间的国际化学合作 (ICC)。研究人员及其国外同行提议开发催化工艺，利用丰富的可再生资源无副产物地生产化学产品，该工艺将设计和制备一系列新型膦配体，其中包含专门为超分子识别元素而设计的膦配体。这些“第一代金属络合物”将在 Krische Group 开发的 C-C 键形成氢化反应中进行分析，以确定关键的结构反应性和结构选择性。趋势将使 Krische 和 Breit 能够设计改进的第二代催化剂，该催化剂将由 Breit 集团制备并由 Krische 集团进行分析。 Krische 和 Breit 集团之间的合作是科学专业知识的理想结合，将通过增强两个集团的能力。直接接触跨大西洋的研究技术、方法、理念和网络。拟议的研究旨在实现大规模有效激活新底物所需的高催化剂活性和选择性，这将增强精细化学品的应用，包括制造该提案的最大影响将是通过研究进行教育，他们将受益于获得合成有机化学、物理有机化学和过渡金属学科技能的独特机会。来自历史上在科学领域代表性不足的群体的学生也将被招募参加“辉瑞代表性不足的少数群体研究奖学金”和美国国立卫生研究院资助的“通往未来的桥梁”等项目。计划，该计划促进少数族裔学生从学士/硕士过渡到博士学位授予机构。此外，Krische 教授还使用 NIH 资助的“促进健康相关研究多样性的研究补充”来指导几名学生。