Phopshine Organocatalysis

磷光有机催化

• 批准号: 0749016
• 负责人: Michael Krische
• 金额: $ 44.6万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0749016&HistoricalAwards=false
• 关键词: Phopshine; Organocatalysis

This project represents a continuation of Professor Krische's efforts toward the development of phosphine catalyzed C-C and C-N bond forming processes. Prior to studies from Professor Krische's group, Morita-Baylis-Hillman type couplings were largely restricted to the use of aldehydes and aldimines as electrophilic partners. The Krische group has expanded the range of electrophilic partners applicable to MBH-type coupling to encompass enones, allylic acetates and arenes. In the proposed funding period, enantioselective variants of these transformations will be devised and other phosphine catalyzed processes will be developed.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Michael J. Krische at the Department of Chemistry and Biochemistry at the University of Texas at Austin. Professor Krische's research program focuses on catalytic reaction development, in particular on byproduct-free processes for C-C and C-N bond formation. The successful development of the proposed methodologies will have a large positive impact on synthetic organic chemistry in the pharmaceutical and agrochemical industries.

该项目代表了 Krische 教授在开发膦催化 C-C 和 C-N 键形成过程方面所做努力的延续。在 Krische 教授小组的研究之前，Morita-Baylis-Hillman 型偶联很大程度上仅限于使用醛和醛亚胺作为亲电伴侣。 Krische 小组扩大了适用于 MBH 型偶联的亲电子伴侣的范围，涵盖烯酮、烯丙乙酸酯和芳烃。在拟议的资助期内，将设计这些转化的对映选择性变体，并开发其他膦催化过程。通过该奖项，有机和高分子化学项目将支持化学和生物化学系 Michael J. Krische 教授的研究在德克萨斯大学奥斯汀分校。 Krische 教授的研究项目侧重于催化反应开发，特别是 C-C 和 C-N 键形成的无副产物过程。 该方法的成功开发将对制药和农化行业的有机合成化学产生巨大的积极影响。