UCSF Environmental Research and Translation for Health Center (EaRTH Center)

加州大学旧金山分校健康中心环境研究与翻译（EaRTH 中心）

• 批准号: 9918111
• 负责人: Tracey J. Woodruff
• 金额: $ 121.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-22 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9918111
• 关键词: Address; Affect; Analytical Chemistry; Animal Model; Bioinformatics; Biological; Biological Assay; Biomedical Research; California; Cell Nucleus; Cell model; Chemical Exposure; Chemicals; Child; Chronic Disease; Clinical; Clinical Medicine; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Community Outreach; Complex; Consultations; Core Facility; Data; Dentistry; Development; Diabetes Mellitus; Discipline; Disease; Educational Curriculum; Environment; Environmental Exposure; Environmental Health; Environmental Risk Factor; Epidemiology; Exposure to; Family; Funding; Future; Goals; Health; Health Professional; Health Sciences; Healthcare; Human; Infrastructure; Institution; International; Intervention; Investigation; Laboratories; Leadership; Link; Location; Longevity; Malignant Neoplasms; Measurement; Measures; Mediating; Medical; Medical Students; Medicine; Mentors; Mentorship; Modeling; National Institute of Environmental Health Sciences; Neurodevelopmental Disorder; Obesity; Pathway interactions; Patients; Peer Review; Pharmacy facility; Pilot Projects; Planet Earth; Positioning Attribute; Prevalence; Prevention; Prevention education; Production; Proteomics; Publishing; Reproduction; Reproductive Health; Research; Research Design; Research Personnel; Resources; Role; San Francisco; School Nursing; Schools; Science; Scientist; Students; Technology; Training; Translating; Translational Research; Translations; Underserved Population; Universities; Vulnerable Populations; Women' s Health; Work; career; data integration; dissemination research; education resources; environmental chemical; environmental stressor; health data; health literacy; healthcare community; high throughput screening; human tissue; improved; in vivo; insight; interdisciplinary collaboration; member; men; next generation; operation; outreach; prevent; programs; ranpirnase; reproductive; social stressor; tool

The overall goal of the new University of California, San Francisco (UCSF) Environmental Research and Translation for Health (EaRTH) Center is to accelerate the pace of recognizing and preventing environmental exposures that affect reproduction and development to improve human health across the lifespan. Addressing the complex problems of environmental health requires partnerships across disciplines; mobilization of technology for identification, intervention, and prevention; and education of future scientists and clinicians and the public. The EaRTH Center is uniquely positioned to address these challenges and advance environmental health. By virtue of its location at UCSF—a premier institution for biomedical research, translation of research findings, and clinical training—and its strong interdisciplinary team, the EaRTH Center will fill a critical gap in a prominent clinical and biomedical research setting. Our proposed UCSF P30 EaRTH Center will allow us to: create opportunities for new research directions in environmental health at UCSF that are not currently possible; nurture and sustain transdisciplinary research collaborations across a network of academics and diverse UCSF departments to advance our understanding of the relationship between environment and disease; mentor and grow the next generation of research and clinical leaders in environmental health; and embed environmental health literacy within health care to accelerate prevention of environmentally mediated diseases. Our Center tightly integrates 4 cores and 1 program: 1) an Administrative Core to provide leadership, infrastructure, administrative and communication support, advice and oversight to coordinate all EaRTH Center operations; 2) an Integrated Health Sciences Facility Core (IHSFC) that will provide consultation on study design, data integration, data of environmental and social stressors, and translation and dissemination of research findings; 3) a Bioassay Facility Core that will provide state-of-the-art tools for measuring chemical exposures and their effects on biological pathways; 4) a Community Engagement Core (CEC) to expand environmental health education and resources for students and health professionals to embed environmental health within health care; and 5) a Pilot Project Program to fund transdisciplinary projects enabling researchers to enter the field or add an environmental component to their current research. Our integrated Center will lead to new scientific understandings in environmental health tightly linked to our community outreach work, which will shift the fundamental understanding of the role of environment in disease, leading to solutions to preventing harmful exposures and improving health.

新加州大学旧金山分校（UCSF）环境研究中心的总体目标 健康翻译 (EaRTH) 中心旨在加快识别和预防疾病的步伐 影响生殖和发育的环境暴露，以改善人类整个生命周期的健康。 解决环境健康的复杂问题需要跨学科的合作； 识别、干预和预防技术；以及对未来科学家和信徒的教育； 地球中心在应对这些挑战和促进环境方面具有独特的地位。 凭借其位于加州大学旧金山分校的地理位置——加州大学旧金山分校是生物医学研究和研究转化的首要机构。 调查结果和临床培训——及其强大的跨学科团队，EaRTH 中心将填补这一领域的关键空白 我们提议的 UCSF P30 EaRTH 中心将使我们能够： 为加州大学旧金山分校环境健康新研究方向创造目前不可能的机会； 培育和维持跨学术网络和加州大学旧金山分校的跨学科研究合作 部门，以增进我们对环境与疾病之间关系的理解； 培养下一代环境健康研究和临床领导者并嵌入环境健康； 医疗保健领域的健康素养，以加速预防环境介导的疾病。 紧密集成 4 个核心和 1 个程序：1) 一个管理核心，提供领导、基础设施、 行政和沟通支持、建议和监督，以协调所有地球中心的运作2) 综合健康科学设施核心（IHSFC）将提供研究设计、数据咨询 环境和社会压力因素的整合、数据以及研究成果的翻译和传播； 3) 生物测定设施核心，将提供最先进的工具来测量化学品暴露及其影响 对生物途径的影响；4) 扩大环境健康的社区参与核心 (CEC) 为学生和卫生专业人员提供教育和资源，将环境健康纳入卫生保健； 5) 试点项目计划资助跨学科项目，使研究人员能够进入该领域或增加一个 我们的综合中心将把环境因素纳入他们当前的研究中，从而带来新的科学成果。 对环境健康的理解与我们的社区外展工作密切相关，这将改变 对环境在疾病中的作用有基本的了解，从而找到预防有害疾病的解决方案 暴露和改善健康。