RUI: Hypervalent Iodine Chemistry

RUI：高价碘化学

• 批准号: 1009038
• 负责人: Viktor Zhdankin
• 金额: $ 40.5万
• 依托单位: University of Minnesota Duluth
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1009038&HistoricalAwards=false
• 关键词: RUI; Hypervalent; Iodine; Chemistry

This project will continue work on the development of new synthetic methodologies based on the chemistry of hypervalent iodine(III) and iodine(V) compounds, which are efficient and environmentally benign oxidizing reagents with numerous applications in organic synthesis. While hypervalent iodine compounds are well-established reagents, little progress has been made in the development of new catalytic reactions promoted by hypervalent iodine. Studies of new, extremely mild and efficient iodine(V)/transition metal tandem catalytic system for the oxidation of hydrocarbons will be investigated using various aryliodides and transition metals as co-catalysts and Oxone as a stoichiometric oxidant. Several other iodoarene-catalyzed oxidative transformations, such as Hofmann rearrangement of amides to amines, preparation of unsaturated carbonyl compounds from ketones, oxidative cleavage of carbon-carbon double bonds, and the iodine(III)-catalyzed enantioselective oxidations will also be studied. An exploratory search for new and potentially useful hypervalent organic compounds will be also performed. In addition, an important objective of this project is to provide excellent training in advanced chemistry research to BS and MS students and to further strengthen predominantly undergraduate research at University of Minnesota Duluth.With this award, the Chemical Synthesis program is supporting the research of Professor Viktor V. Zhdankin of the Department of Chemistry and Biochemistry at University of Minnesota Duluth. Professor Zhdankin's research efforts revolve around the development of facile oxidative methods based on hypervalent iodine chemistry. Such chemistry will contribute to environmentally benign methods for chemical synthesis as it utilizes non-toxic compounds of iodine as catalysts or recyclable reagents in aqueous solutions. Successful development of the methodology will have an impact on synthesis in the pharmaceutical industry.

该项目将继续基于高价值碘（III）和碘（V）化合物的化学发展新合成方法的开发，这些化合物是有效且环境良性的氧化试剂，并在有机合成中使用了许多应用。虽然高价值碘化合物是公认的试剂，但在通过高价值碘推动的新催化反应的发展中取得了很少的进展。 将使用各种芳基碘化物和过渡金属作为共催化剂和牛酮作为一种石化的氧化剂研究，研究新的，极度和高效的碘（V）/过渡金属催化系统，用于氧化碳氢化合物。 其他几种碘芳烃催化的氧化转化，例如胺向胺向胺的Hofmann重排，从酮的不饱和羰基化合物制备，碳碳双键的氧化裂解，以及碘（III）（III） - 催化剂的enantioseal氧化氧化也将进行研究。 还将进行探索性搜索，以探索新的且潜在的高价值有机化合物。 此外，该项目的一个重要目的是为BS和MS学生提供出色的高级化学研究培训，并在明尼苏达大学Duluth大学中进一步加强本科生的研究。由于该奖项，化学合成计划正在支持Viktor V. Zhdankin教授的化学和生物学系教授的研究。 Zhdankin教授的研究工作围绕基于高价值碘化学的易于氧化方法的发展。 这种化学物质将有助于化学合成的环境良性方法，因为它利用了碘的无毒化合物作为催化剂或水溶液中可回收试剂。 该方法的成功开发将对制药行业的合成产生影响。