GOALI: Semi-Packed Gas Separation Columns with Monolayer-Protected Gold Phases

GOALI：具有单层保护金相的半填充气体分离柱

• 批准号: 1002279
• 负责人: Masoud Agah
• 金额: $ 35.03万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2014-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1002279&HistoricalAwards=false
• 关键词: GOALI; Semi; Packed; Gas; Separation

GOALI: Semi-Packed Gas Separation Columns with Monolayer-Protected Gold PhasesThe objective of this proposal is to introduce a new architecture for GC columns named semi-packed and a new method for stationary phase coating. The approach is to use MEMS technology for the fabrication of semi-packed columns and to utilize nanotechnology to uniformly functionalize the column surfaces.Intellectual Merit: The proposed semi-packed columns consist of a microfluidic channel with an embedded array of ordered pillars (posts). These new columns, which do not have any conventional counterpart, offer both higher sample capacities and higher separation efficiencies. Four specific goals are proposed: 1) fabricating semi-packed columns with on-chip heaters and temperature sensors, 2) depositing functionalized gold nanoparticles or gold thin films on all surfaces of the MEMS-based columns with nanometer resolutions, 3) evaluation of the performance of MEMS columns with their monolayer-protected gold phases, and 4) coating the MEMS columns with commercial phases under industrial conditions to analyze their performance against those coated with proposed stationary phases. Broader Impacts: The outcome of this project will set an outstanding example of how MEMS and Nanotechnology can become highly complementary methodologies to develop low-cost, low-power, high-performance microdevices. This research will also advance discovery while promoting teaching and learning through research opportunities for undergraduates, recruiting of graduate students into a highly interdisciplinary research program, incorporation of the project results in the courses taught by the PIs in different departments/institutions, and annual joint seminars by Virginia Tech, College of William and Mary, and Restek Corporation on micro gas chromatography and novel stationary phases.

目标：具有单层保护金相的半填充气体分离柱该提案的目的是引入一种名为半填充的气相色谱柱新架构和一种新的固定相涂层方法。该方法是利用 MEMS 技术制造半填充柱，并利用纳米技术对柱表面进行统一功能化。 优点：所提出的半填充柱由微流体通道和嵌入式有序柱阵列组成。 。这些新型色谱柱没有任何传统的对应物，可提供更高的样品容量和更高的分离效率。提出了四个具体目标：1）制造带有片上加热器和温度传感器的半填充柱，2）以纳米分辨率在基于 MEMS 的柱的所有表面上沉积功能化金纳米粒子或金薄膜，3）评估具有单层保护金相的 MEMS 色谱柱的性能，以及 4) 在工业条件下用商用固定相涂覆 MEMS 色谱柱，以分析其与涂有建议固定相的色谱柱的性能。更广泛的影响：该项目的成果将为 MEMS 和纳米技术如何成为开发低成本、低功耗、高性能微型设备的高度互补的方法论树立一个杰出的例子。这项研究还将通过为本科生提供研究机会、招募研究生参加高度跨学科的研究项目、将项目成果纳入不同部门/机构的 PI 教授的课程以及年度联合研讨会，在促进教学和学习的同时推进发现。由弗吉尼亚理工大学、威廉玛丽学院和 Restek 公司开发的微气相色谱和新型固定相。