Development of a 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

21特斯拉傅里叶变换离子回旋共振质谱仪的研制

• 批准号: 0938158
• 负责人: Alan Marshall
• 金额: --
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0938158&HistoricalAwards=false
• 关键词: Development; 21; Tesla; Fourier; Transform

DMR-0938158PIs: Boebinger, MarshallThis award will fund the design, construction, and optimization of performance of a 21 Tesla ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometer(FTICR-MS). The rationale for this project draws from the workshop, "Science Challenges and Design Concepts for the Next-Generation High-Performance FT-ICR Mass Spectrometer," organized jointly by National High Magnetic Field Laboratory (NHMFL) and the Environmental Molecular Scienes Laboratory (EMSL), and held on 16-17 January, 2008 at NHMFL. Feasibility of the magnet design has been demonstrated by NHMFL's Magnet Science and Technology group, and three vendors have offered to build it. The other components of the spectrometer will be designed and built by NHMFL permanent staff and two postdoctoral researchers. Ion optics design will be guided by large-scale supercomputer simulations (modeling the interaction of more than 1,000,000 ions). This project will improve every aspect of technical performance: sample introduction, ion source(s), ion transmission, ion external accumulation, ion cyclotron resonance (ICR) excitation and detection, computerized and automated instrument control, higher magnetic field, and data reduction. Magnet delivery will take three years, allowing for extensive progress in design of the rest of the instrument in the interim. Applications will focus on petroleomics, top-down proteomics, and hydrogen/deuterium exchange to map contact surfaces in biomacromolecular complexes.

DMR-0938158PIS：Boebinger，Manshallthis Award将资助21 Tesla Ultrahigh分辨率傅立叶转换离子离子离子谐振质谱仪（FTICR-MS）的设计，构建和优化。该项目的基本原理摘自研讨会，“科学挑战和设计概念是针对国家高磁场实验室（NHMFL）共同组织的下一代高性能FT-ICR质谱仪的”，环境分子实验室（NHMFL）和2008年1月16日至17日在NHMFL举行。 NHMFL的磁铁科学技术集团已经证明了磁铁设计的可行性，并提出了三家供应商来构建它。光谱仪的其他组件将由NHMFL永久人员和两名博士后研究人员设计和建造。离子光学设计将由大型超级计算机模拟（对超过100万离子的相互作用进行建模）进行指导。该项目将改善技术性能的各个方面：样品引入，离子源，离子传输，离子外部积累，离子回旋共振（ICR）激发和检测，计算机化和自动化仪器控制，较高的磁场和数据减少。磁铁的传递将需要三年的时间，从而在此期间的其余仪器设计方面取得了广泛的进展。应用将集中于石油学，自上而下的蛋白质组学和氢/氘交换，以绘制生物acromotomolecular络合物中的接触表面。