MRI: Acquisition of a TOF High Resolution Mass Spectrometer

MRI：购买 TOF 高分辨率质谱仪

• 批准号: 0923097
• 负责人: Ross Widenhoefer
• 金额: $ 18.79万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923097&HistoricalAwards=false
• 关键词: MRI; Acquisition; TOF; Resolution; Mass

With this award from the Major Research Instrumentation (MRI) program, the Chemistry Department at Duke University will acquire a LC-TOF high resolution mass spectrometer for use in teaching and research. A variety of research projects will be investigated including: Chemical Tools to Manipulate Metal-Catalyzed Oxidative Stress, Catalytic Hydrofunctionalization, Modular Recombinant Transporter-Assisted Nuclear Delivery for AGT Imaging, Self-healing Polymers, Energy Transduction Mechanisms, Design of New Imaging Agents, Chemical Approaches to the Elucidation of Cell Signaling Pathways, the Cellulosome, Catalytic Nanolithography, Biologically-Inspired Small Molecule Synthesis, and Bioorganic Mechanisms of Peptide Antibiotics. Mass spectrometry (MS) is used to identify the chemical composition of a sample and determine its purity by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. Chromatography is an isolation technique that precedes the mass spectrometry analysis. It separates a mixture into its several constituent chemicals which are then analyzed by the mass spectrometer. These are widely used analytical techniques to identify and quantify the chemical composition of a sample. The acquisition will benefit undergraduate chemistry students through existing, intensive research outreach programs in the Department and through utilization of the mass spectrometer in the undergraduate chemistry laboratories.

通过主要研究工具（MRI）计划的奖项，杜克大学的化学系将获得LC-TOF高分辨率质谱仪用于教学和研究。 A variety of research projects will be investigated including: Chemical Tools to Manipulate Metal-Catalyzed Oxidative Stress, Catalytic Hydrofunctionalization, Modular Recombinant Transporter-Assisted Nuclear Delivery for AGT Imaging, Self-healing Polymers, Energy Transduction Mechanisms, Design of New Imaging Agents, Chemical Approaches to the Elucidation of Cell Signaling Pathways, the Cellulosome, Catalytic Nanolithography,肽抗生素的生物启发的小分子合成和生物有机机制。质谱法（MS）用于鉴定样品的化学成分，并通过测量样品被电离并通过质谱仪检测到样品中的分子成分的质量来确定其纯度。 色谱法是质谱分析之前的隔离技术。 它将混合物分离成其几种组成化学物质，然后通过质谱仪分析。 这些是广泛使用的分析技术，可以识别和量化样品的化学组成。 此次收购将通过部门中现有的强化研究外展计划以及通过本科化学实验室中的质谱仪利用来使本科化学学生受益。