Catalytic Addition of Nucleophiles to Unactivated Olefins

亲核试剂与未活化烯烃的催化加成

基本信息

批准号：
0555425
负责人：
Ross Widenhoefer
金额：
$ 41.1万
依托单位：
Duke University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2006
资助国家：
美国
起止时间：
2006-05-01 至 2010-01-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0555425&HistoricalAwards=false
关键词：
Catalytic Addition Nucleophiles Unactivated Olefins

Catalytic Addition Nucleophiles Unactivated Olefins

项目摘要

This project addresses the development of Pd(II)-, Pt(II)-, and Au(I)-catalyzed processes for the addition of C-, N-, and O-nucleophiles to unactivated olefins. The scope of the Pt-catalyzed alkylation of indoles will be explored, and an effective protocol for the asymmetric cyclization of allenyl indoles will be developed. The Pt-catalyzed hydroamination of alkenyl amines and methodologies for the hydroamination of alkenyl carbamates will also be explored. Additional reactions slated for examination include intramolecular hydroamination of allenes, intermolecular hydroamination of unactivated olefins, Pd-catalyzed cyclization/carboalkoxylation of alkenyl indoles, and Pt-catalyzed hydroalkoxylation of hydroxy olefins. A summer exchange program with North Carolina Central University (NCCU) will bring undergraduate researchers from NCCU to Duke University.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Ross A. Widenhoefer, of the Department of Chemistry at Duke University. Dr. Widenhoefer is exploring new synthetic methods for the conversion of simple organic molecules into more complex molecules containing new carbon-carbon, carbon-nitrogen, and carbon-oxygen bonds. By exploiting the novel chemistry of compounds containing metal atoms, in particular palladium, platinum, and gold, Dr. Widenhoefer is developing simple tools for the construction of complex naturally-occurring and biologically active molecules, with potential applications in the areas of manufacturing, fine chemical production, and pharmaceutical discovery and synthesis. In addition to Duke University students, this research program engages undergraduate students from North Carolina Central University through a summer research exchange program.

该项目介绍了Pd（ii），Pt（ii） - 和Au（i）催化过程的开发，用于将C-，N-和O-核粉添加到未激活的烯烃中。将探索吲哚的PT催化烷基化的范围，并将开发出有效的甲烯基吲哚底物的有效方案。还将探索烷胺的PT催化盐水和烷基氨基甲酸酯氢化方法的方法。用于检查的其他反应包括艾肠内分子内氢化，未激活的烯烃的分子间氢化，烷基吲哚的PD催化环化/碳氧基化以及PT催化的羟基羟基化羟基氧化氢烯基的羟基氧化物。与北卡罗来纳州中央大学（NCCU）的夏季交流计划将将本科研究人员从NCCU带到杜克大学。随着该更新奖，有机和巨型分子化学计划正在支持杜克大学化学系的Ross A. Widenhoefer博士的研究。 Widenhoefer博士正在探索新的合成方法，以将简单的有机分子转化为更复杂的分子，这些分子含有新的碳碳，碳氮和碳氧键。通过利用含有金属原子的化合物的新化学性质，尤其是钯，铂和黄金，Widenhoefer博士正在开发简单的工具，用于构建复杂的自然存在和生物学活性分子，并在制造，化学生产以及药物生产以及药物发现和合成的领域中具有潜在的应用。除了杜克大学的学生外，该研究计划还通过夏季研究交流计划与来自北卡罗来纳州中央大学的本科生一起。