International Collaboration in Chemistry: Transition Metal-Mediated C-C Bond and C-Heteroatom Bond Formations via C-H Activation in Organic Synthesis

化学国际合作：有机合成中通过 C-H 活化过渡金属介导的 C-C 键和 C-杂原子键形成

基本信息

批准号：
0922998
负责人：
Chuan He
金额：
$ 41.3万
依托单位：
University of Chicago
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-15 至 2012-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0922998&HistoricalAwards=false
关键词：
International Collaboration Chemistry Transition Metal

项目摘要

This project will explore the development of new methods for the formation of C-C and C-N bonds via platinum-catalyzed C-H activation reactions. Although platinum complexes are known to mediate C-H activation to form alkyl-platinum or aryl-platinum species, few studies have been directed toward formation of C-C or C-N bonds from these intermediates. Development of new platinum-mediated methods for formation of C-C and C-N bonds from direct functionalization of C-H bonds will be undertaken. The reaction mechanism will be elucidated and the new methods will be employed in the synthesis of complex molecules. Applications of these new reactions in the synthesis of natural products will be performed by Professor He's Chinese collaborator, Professor Yong-Qiang Tu, of Lanzhou University. Professor Tu's work is separatately supported by the National Science Foundation of China (NSFC). This International Collaborations in Chemistry award, funded by the Organic and Macromolecular Chemistry Program and the Office of International Science and Engineering, will support the work of Professor Chuan He, of the Department of Chemistry at the University of Chicago. Professor He's research efforts revolve around the development of facile C-H activation methods for the formation of C-C and C-N bonds. Such chemistry will contribute to energy efficient and environmentally benign synthesis of various chemical and pharmaceutical agents.

该项目将探索通过铂催化的C-H激活反应形成C-C和C-N键的新方法。尽管已知铂络合物可以介导C-H激活形成烷基 - 白斑或芳基 - 铂种，但很少有研究针对这些中间体的C-C或C-N键形成。将开发新的铂介导的方法，用于形成C-C和C-N键，直接通过C-H键的功能化。将阐明反应机制，并将采用新方法来合成复杂分子。这些新反应在合成天然产品中的应用将由HE教授的中国合作者，兰州大学的Yong-Qiang Tu教授进行。 Tu教授的工作得到了中国国家科学基金会（NSFC）的分离支持。由有机和大分子化学计划和国际科学与工程办公室资助的这项国际化学合作奖将支持芝加哥大学化学系Chuan He教授的工作。教授他的研究工作围绕着C-C和C-N键形成的便利C-H激活方法的发展。这种化学将有助于各种化学和药物的能源效率和环境良性合成。