SGER: Single Nanoparticle Surface Plasmon Resonance Imaging

SGER：单纳米粒子表面等离子共振成像

• 批准号: 0918189
• 负责人: Karl Booksh
• 金额: $ 15万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0918189&HistoricalAwards=false
• 关键词: SGER; Single; Nanoparticle; Surface; Plasmon

"This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)."Professor Karl S. Booksh of the University of Delaware is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to develop a scanning, single particle surface plasmon resonance spectroscopy technique to be applied for label-free imaging of nanoscale heterogeneous materials. A single gold or silver nanoparticle will be placed on the tip of an optical fiber probe of a near-field scanning optical microscope. The plasmon field will be shaped and focused by adjusting the size and morphology of the nanoparticle probe. Refractive index changes on the probed surface will affect the surface plasmon resonance frequency of the particle immobilized at the tip of the probe. This will enable the high-resolution mapping of local dielectric constants of nanoscale heterogeneous materials without the need for dyes or reporter molecules. Such a high resolution, non-invasive imaging method is currently not available. The proposed imaging technique will be useful for characterization of surfaces of materials such as SAMs, lipid bilayers, and soft polymers, and will lead to innovations in nanoscience and technology, surface chemistry, and biotechnology.

"This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)."Professor Karl S. Booksh of the University of Delaware is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to develop a scanning, single particle surface plasmon resonance spectroscopy technique to be applied for label-free imaging of nanoscale heterogeneous materials. 单个金或银纳米颗粒将放在近场扫描光学显微镜的光纤探针的尖端上。血浆场将通过调节纳米颗粒探针的大小和形态来形成和聚焦。 探测表面上的折射率变化将影响固定在探针尖端的粒子的表面等离子体共振频率。这将使纳米级异质材料的局部介电常数进行高分辨率映射，而无需染料或记者分子。 目前尚不可用这种高分辨率的非侵入成像方法。 提出的成像技术将有助于表征SAM，脂质双层和软聚合物等材料表面，并将导致纳米科学和技术，表面化学和生物技术的创新。