Integrative Modeling/Simulation and Experimental Validation of Therapeutic Nanodiamond Materials

治疗性纳米金刚石材料的综合建模/模拟和实验验证

• 批准号: 0856492
• 负责人: Dean Ho
• 金额: $ 113.12万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0856492&HistoricalAwards=false
• 关键词: Integrative; Modeling; Simulation; Experimental; Validation

Nanodiamonds possess several properties that enable their versatile application towards drug delivery. For example, they can carry and release proteins, small molecules, genetic material, etc. They can also be applied as particle-based vehicles for pervasive delivery, or integrated within devices for localized treatment. To optimize the therapeutic potential of the nanodiamonds, a broader understanding of their chemical/mechanical properties will be addressed by this research program. This information will uncover the fundamental science underlying nanodiamond particle structure, chemical composition/distribution on nanodiamond surfaces, and drug attachment/detachment mechanisms, etc. This program unites complementary expertise in mechanical/biomedical engineering, chemistry, and engineering education research towards the comprehensive analysis of fundamental nanodiamond properties via atomistic, quantum, and continuum modeling/simulations. Information gleaned from these studies will be integrated with experimental validation towards the intelligent design of therapeutic nanodiamond particles and devices.This program will merge nanodiamond and engineering education research to train the next generation of scientific/engineering leaders. The educational/outreach plan will integrate educational module design, faculty guest lectures, and custom designed experimental kits to impact a diverse student population and increase nanotechnology interest. These modules will also be co-designed with partner teachers. Module topics will include an introduction to nanocarbon materials/devices, nanobiology, etc. Images derived from the modeling/simulation project objectives will be used to accomplish the challenge of visually illustrating nanotechnology concepts. Module/experimental kit implementation will be coordinated by postdoctoral researchers and graduate students, and feedback/analysis of the outreach program efficacy will be conducted in collaboration with the Northwestern Center for Engineering Education Research.

纳米符号具有多种特性，可将其多功能应用于药物输送。例如，它们可以携带和释放蛋白质，小分子，遗传物质等。它们也可以用作基于粒子的车辆以进行普遍递送，或在设备中集成以进行局部处理。为了优化纳米符号的治疗潜力，该研究计划将对它们的化学/机械性能有更广泛的了解。该信息将揭示纳米原子粒子结构的基本科学，纳米原子表面上的化学组成/分布以及药物依恋/分离机制等。该程序将机械/生物医学工程，化学和工程教育研究中的机械/生物医学工程和工程教育研究中的互补专业知识统一，以通过基础Nanodiamond Properties进行基础的构建/数量的模型，并进行了数量，并且可以进行量身定量，并且可以进行量身定量，并且具有量级的模型。从这些研究中收集的信息将与实验验证集成，以实现治疗性纳米座颗粒和设备的智能设计。该计划将合并纳米山脉和工程教育研究，以培训下一代科学/工程领导者。 教育/外展计划将整合教育模块的设计，教师的客座讲座以及定制设计的实验套件，以影响多样化的学生人数并增加纳米技术的兴趣。这些模块也将与合作伙伴老师共同设计。模块主题将包括纳米碳材料/设备，纳米生物学等介绍。源自建模/仿真项目目标的图像将用于实现视觉上说明纳米技术概念的挑战。模块/实验套件实施将由博士后研究人员和研究生协调，并且将与西北工程教育研究中心合作进行外展计划功效的反馈/分析。