U.S.-Japan Planning Visit: Hormonal control of body fluid homeostasis in fish; Interactions between fast-acting and slow-acting hormones

美日计划访问：鱼类体液稳态的激素控制；

• 批准号: 0852518
• 负责人: E. Gordon Grau
• 金额: $ 1.98万
• 依托单位: University of Hawaii
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0852518&HistoricalAwards=false
• 关键词: U.S.; Japan; Planning; Visit; Hormonal

OISE-0852518 (Grau, University of Hawaii) ?Hormonal control of body fluid homeostasis in fish: Interactions between fast-acting hormones and slow-acting hormones?Abstract This award supports planning and early-stage collaborative research activities between PI Grau and Professor Yoshio Takei of the University of Tokyo to further develop comparative studies on two euryhaline teleosts, eel and tilapia, to elucidate shared mechanisms that are employed in osmotic and ionic regulation in the face of large changes in environmental salinity. These fishes are ideal models for comparative studies, since they share many features in common with higher vertebrates including humans that are involved in homeostasis of body fluids. Hormones involved in osmoregulatory adaptation in fish can be classified into two categories; fast-acting hormones and slow- but long-acting hormones. Interactions between the two categories of the hormones are not well understood. The goals of the proposal are to 1) integrate areas of scientific inquiry that are typically distinct and separate from one another, i.e., fast-acting hormones vs. long-lasting hormones, and eel vs. tilapia; 2) initiate collaborative research to identify key genes and proteins that regulate activities of relevant endocrine systems in both eel and tilapia in response to environmental changes in salinity; 3) develop new methods, concepts and approaches by exposing young scientists to a unique mixture of knowledge and training not available in a single laboratory, and 4) foster personal and professional relationships that will extend beyond the proposed work. Young scientists, postdoctoral fellows and graduate students, and faculty on both sides will participate in minisymposia and workshops as well as have short-term training experiences in Dr. Takei?s lab.

OISE-0852518（夏威夷大学GRAU）？荷尔蒙对鱼体内稳态的荷尔蒙控制：快速作用激素与缓慢作用的激素之间的相互作用？该奖项摘要支持计划与Pi Grau和Pi Grau和Pi Grau教授Yoshio Take of Tokey of Tokyeriia和Toky ekyer的早期协作活动，以开发两种ekeriia the ekeriia eyer的研究，以进一步发展。阐明面对环境盐分的巨大变化，这些机制在渗透和离子调节中采用。这些鱼是比较研究的理想模型，因为它们具有许多与较高脊椎动物共同的特征，包括与人体液体稳态有关的人类。涉及鱼类渗透调节适应的激素可以分为两类；快速作用的激素和缓慢但长效的激素。激素两类之间的相互作用尚不清楚。该提案的目标是1）整合了通常与彼此不同的科学询问领域，即快速效应的激素与持久的荷尔蒙，以及鳗鱼vs. tilapia； 2）启动协作研究以确定关键基因和蛋白质，以响应盐度的环境变化，以调节鳗鱼和罗非鱼相关内分泌系统的活动； 3）通过将年轻科学家暴露于独特的知识和培训的独特混合物中，而在单个实验室中不提供知识和培训的独特结合，而4）培养个人和专业关系将超越拟议的工作。年轻的科学家，博士后研究员和研究生以及双方的教职员工将参加迷你典礼和讲习班，并在Takei博士实验室中获得短期培训经验。