CAREER: Research, Education, and Capacity Building - Genomic Structure of Native Peruvian Populations

职业：研究、教育和能力建设——秘鲁原住民的基因组结构

• 批准号: 0845314
• 负责人: Cecil Lewis
• 金额: $ 64.49万
• 依托单位: University of Oklahoma Norman Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0845314&HistoricalAwards=false
• 关键词: CAREER; Research; Education; Capacity; Building

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The CAREER project integrates next-generation molecular genetics with an aggressive education strategy to prepare students and professionals in genomics and to communicate the importance of science to the public. The research questions asked are: What is the geographic pattern of human population diversity? and, How have migrations, the environment, and culture shaped this pattern? Addressing these questions provides a foundation for numerous fields of biological and medical science including the study of natural selection, the search for disease predisposing genes, and the handling of confounding factors in disease association research that are attributed to modern genetic exchange.The country of Peru will serve as a ideal case study: 1) to date, only one population in Peru has been studied at a genomic level; 2) Peru is ecologically diverse, with deserts, high plateaus, and the Amazon Jungle; 3) Peru has an extremely rich cultural prehistory and extensive present-day linguistic and ethnic diversity. The genomic data will be informative of sex-biased patterns of migration, the extent of genetic admixture between native and non-native peoples, and the role of geographic and linguistic barriers on patterns of human genetic diversity. The genetic data includes mitochondrial genomes and a genome-wide survey of 800 repeat motifs for 15 geographically dispersed native populations. These novel data will be integrated with previously published data providing the most extensive genomic sampling of human populations to date. Education activities will reach a broad audience by accounting for varied levels of training in biological science. They include an annual professional development workshop for high school and community college teachers, a course and hands-on experience in genetics for undergraduate students, courses and hands-on training in genomics for graduate students, capacity building in Peru, public education using an online course, and the dissemination of the research by a project website. This project will employ one professional, full-time technician who is Hispanic, and a number of undergraduate and graduate students will participate as research interns during the duration of the research.

该奖项是根据2009年的《美国复苏与再投资法》（公法111-5）资助的。职业项目将下一代分子遗传学与积极的教育策略相结合，以使学生和专业人士在基因组学领域做好准备，并将科学的重要性传达给公众。研究问题是：人口多样性的地理模式是什么？而且，迁移，环境和文化如何塑造这种模式？解决这些问题为众多生物学和医学科学领域提供了基础，包括对自然选择的研究，易感疾病的疾病以及疾病协会研究中的混杂因素的处理，这些研究归因于现代遗传交换。秘鲁的国家将作为一个理想的案例研究：1），迄今为止，秘鲁只有一个人口在秘鲁的一个种类阶段层面研究过； 2）秘鲁在生态上是多样的，有沙漠，高原和亚马逊丛林； 3）秘鲁拥有极富丰富的文化史无前例和广泛的语言和种族多样性。基因组数据将为性别偏见的迁移模式，天然和非本地人之间的遗传混合程度以及地理和语言障碍在人类遗传多样性模式中的作用提供信息。遗传数据包括线粒体基因组和针对15个地理分散本地种群的800个重复基序的全基因组调查。这些新型数据将与先前发布的数据集成，从而提供迄今为止人类种群最广泛的基因组采样。教育活动将通过考虑生物科学的不同培训水平来吸引广泛的受众。其中包括为高中和社区大学教师举办的年度专业发展研讨会，本科生的遗传学课程和动手经验，研究生的基因组学课程和动手培训，秘鲁的能力建设，使用在线课程的公共教育以及项目网站的研究传播。 该项目将聘请一名专业的全职技术人员，他是西班牙裔，许多本科生和研究生将在研究期间作为研究实习生参加。