Evolution of Reliable and Robust Regulatory Control

可靠、稳健的监管控制的演变

• 批准号: 0822399
• 负责人: Steven Frank
• 金额: $ 35.77万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0822399&HistoricalAwards=false
• 关键词: Evolution; Reliable; Robust; Regulatory; Control

Organisms are designed to be reliable and to deal robustly with unexpected changes in the environment. Like machines designed by engineers, the reliability and robustness of organisms is far from perfect. In engineering terms, machines that last a very long time and handle a wide variety of unexpected situations are very expensive and often poorly suited to their tasks - thus, engineers design with both costs and benefits in mind. This project examines the same sorts of design tradeoffs in biological terms. For example, how have organisms been designed with regard to reliability and robustness? How have the tradeoffs between costs and benefits been resolved in biological design? This work will study biological examples of breakdown and repair from these design perspectives. The methods include mathematical and computer models to study the problems of biological design coupled with synthesis of real-life examples of breakdown, such as cancer, aging, and, molecularly, the smaller-scale components that make organisms work. These studies will result in improved understanding of biological reliability and robustness. That understanding will have broader impacts by providing insight into when and why breakdown occurs - the fundamental basis of disease and aging.

有机体的设计是可靠的，并能够牢固地应对环境中的意外变化。 像工程师设计的机器一样，生物的可靠性和鲁棒性远非完美。 用工程术语来说，持续很长时间并处理各种意外情况的机器非常昂贵，而且通常不适合其任务 - 因此，工程师设计的成本和收益都考虑到了。 该项目从生物学的角度研究了相同的设计权衡。 例如，如何设计有机体在可靠性和鲁棒性方面？ 在生物设计中如何解决成本和收益之间的权衡？ 这项工作将从这些设计角度研究崩溃和修复的生物学例子。 这些方法包括数学和计算机模型，以研究生物设计的问题，再加上现实生活中的细分实例，例如癌症，衰老和分子，即使生物体起作用的较小尺度成分。 这些研究将提高人们对生物学可靠性和鲁棒性的了解。 这种理解将通过提供何时以及为什么发生崩溃的洞察力 - 疾病和衰老的基本基础，从而产生更广泛的影响。