Controlled Polymerization of Amino Acid N-Carboxyanhydrides

氨基酸 N-羧酸酐的受控聚合

• 批准号: 0809420
• 负责人: Jianjun Cheng
• 金额: $ 39万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0809420&HistoricalAwards=false
• 关键词: Controlled; Polymerization; Amino; Acid; Carboxyanhydrides

This project aims at the development of new methods for the synthesis of polypeptides with well defined structures. Polypeptides are a class of biomaterials with numerous applications. The most economical process for synthesizing high molecular-weight polypeptides in large-scale is through the polymerization of alpha-amino acid N-carboxyanhydrides with amines as the initiators. Although polypeptides can be readily synthesized using this process, the resulting polypeptides have uncontrolled molecular weights, broad molecular weight distributions, and poorly defined end groups. This project will study the in situ silylation of amine initiators for the controlled polymerization of alpha-amino acid N-carboxyanhydrides. With this grant, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jianjun Cheng of the Department of Materials Science and Engineering at the University of Illinois at Urbana-Champaign. Professor Cheng's research efforts involve the development of initiators for the controlled polymerization of alpha-amino acid N-carboxyanhydrides. Such chemistry will allow control over the end groups as well as the polypeptide molecular weight distribution. Successful development of this methodology has significant impact on both the pharmaceutical and biomaterials industries.

该项目旨在开发具有具有良好定义结构的多肽合成的新方法。 多肽是一类具有多种应用的生物材料。 大规模合成高分子量多肽的最经济的过程是通过将α-氨基酸N-羧基氢化物与胺作为发起人的聚合。 尽管可以使用此过程很容易合成多肽，但所得的多肽具有不受控制的分子量，广泛的分子量分布和定义较差的终极组。 该项目将研究胺 - 氨基酸N-羧基氢化物的受控聚合的胺启动器的原位硅烷基化。 有了这项赠款，有机和大分子化学计划正在支持伊利诺伊大学伊利诺伊大学伊利诺伊大学伊利诺伊大学伊利诺伊大学伊利诺伊大学材料科学与工程系教授的研究。 Cheng教授的研究工作涉及开发α-氨基酸N-羧基氢化物的受控聚合的发起人。 这种化学将允许控制末端组以及多肽分子量分布。 这种方法的成功开发对制药和生物材料行业都有重大影响。