CAREER: Development of Conjugated Polymer-Drug Nanoparticulate Delivery Vehicles

职业：共轭聚合物-药物纳米颗粒输送载体的开发

• 批准号: 0748834
• 负责人: Jianjun Cheng
• 金额: $ 62.5万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0748834&HistoricalAwards=false
• 关键词: CAREER; Development; Conjugated; Polymer; Drug

This Career award by the Biomaterials program in the Division of Materials Research to University of Illinois is to develop synthetic chemistry tools to facilitate the formation of polymeric lactic acid nanoparticle utilizing drug-initiated ring-opening polymerization that precisely controls the formation of nanoparticle drug delivery system. This polymerization approach, where drug is attached to the terminal of polymer chains during polymerization would have the following unique characteristics. 1) Drug loading to polymers is completed in a drug-initiated, living polymerization process instead of being conjugated or encapsulated to an existing polymer; 2) Drug molecules quantitatively coordinate with metal catalysts and facilitate quantitative chain initiation and complete monomer consumption in the polymerization; and 3) Drug release kinetics is modulated by the degradation of polymer matrix and the hydrolysis kinetics of the cleavable polymer-drug bond with low or no burst release effect. By this approach, drug incorporation efficiency could reach 100%, and drug loading could be controlled by adjusting monomer/drug ratio. The scientific broader impact of this project is possible development of well-controlled drug delivery technologies using drug polymer particulates with clear application in medicine and food industryThe project will develop unique and innovative education and outreach programs, such as the development of a workshop on nanobiomaterials for undergraduates and mentoring these students. K-12 students will participate in the project through the Engineering Summer Programs. During the course of this project, the PI plans to develop three biomaterials courses focusing on synthesis and biomedical applications of biomaterials. In addition, a senior undergraduate course will be developed and this course will cover regulatory, legal and business aspects of biomaterials, integrating the PI's interactions with the Tech Transfer Office.

生物材料计划在伊利诺伊大学的材料研究部门获得的职业奖是为了开发合成化学工具，以促进使用药物引起的聚合式聚合聚合的聚合物乳酸纳米颗粒的形成，从而精确控制纳米粒子药物递送系统的形成。 这种聚合方法，其中在聚合过程中附着在聚合物链末端的药物将具有以下独特特征。 1）在药物引发的，生物聚合过程中完成对聚合物的药物载荷，而不是被共轭或封装到现有聚合物中； 2）药物分子与金属催化剂进行定量坐标，并促进定量链的起始和完全的单体消耗； 3）药物释放动力学是通过聚合物基质的降解和可切除的聚合物 - 毒物键的降解和低爆发释放效应的。通过这种方法，药物掺入效率可以达到100％，并且可以通过调整单体/药物比率来控制药物加载。 该项目的科学广泛影响是使用在医学和食品行业中使用明确应用的药物聚合物颗粒来发展良好的药物输送技术，该项目将开发独特而创新的教育和外展计划，例如开发针对本科生和指导这些学生的纳米生物材料研讨会。 K-12学生将通过工程夏季计划参加该项目。在该项目的过程中，PI计划开发三个生物材料课程，重点是生物材料的合成和生物医学应用。 此外，还将开发一门高级本科课程，本课程将涵盖生物​​材料的监管，法律和业务方面，将PI与技术转移办公室的互动整合在一起。