Research Starter Grant: The Genetics of Complex Phenotypes in Drosophila

研究启动资金：果蝇复杂表型的遗传学

基本信息

批准号：
0805818
负责人：
William Frankino
金额：
$ 5万
依托单位：
University of Houston
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2008
资助国家：
美国
起止时间：
2008-05-15 至 2009-04-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0805818&HistoricalAwards=false
关键词：
Research Starter Grant Genetics Complex

项目摘要

Most complex quantitative traits, such as growth rate, virulence, disease susceptibility, ageing or longevity, are actually multivariate trait suites comprised of smaller, individual elements. The evolution of such complex trait suites is predicted to be affected by the number of genes contributing to (co)variation within the trait suite, the strength and additivity of gene effects, and the degree and nature of interactions among these genes (i.e., the genetic architecture of the trait suite). Unfortunately, the genetic architecture of variation in complex, quantitative traits is largely unknown. The proposed research employs a novel introgression approach to isolate genomic regions responsible for variation in wing shape between two closely related Drosophila species. These regions will be identified by using a genome-wide, fine scale mapping approach. By combining this introgression and mapping approach, this research promises to reveal the complex, fine-scale genetic architecture of a model quantitative trait.The proposed research program represents a new way of studying the genetics of complex trait suites in animals and consequently, it will deliver methodologies that can be used to pry open elusive genetic architectures underlying variation in complex traits in other biological systems. This will generate the empirical data that are sorely needed to test predictions of the nascent, generalizable theory of development and evolution.

大多数复杂的定量性状，例如生长速率，毒力，疾病易感性，衰老或寿命，实际上是由较小的个体元素组成的多元特征套件。预计这种复杂性状套件的演变会受到特征套件内（CO）变异的基因数量的影响，基因效应的强度和加性以及这些基因之间相互作用的程度和性质（即，性状套件的遗传结构）。不幸的是，复杂，定量性状变异的遗传结构在很大程度上是未知的。拟议的研究采用了一种新型的渗入方法来分离导致两种密切相关的果蝇物种之间机翼形状变化的基因组区域。这些区域将通过使用全基因组的精细尺度映射方法来识别。通过结合这种研究和映射方法，这项研究有望揭示模型定量特征的复杂，细小的遗传结构。拟议的研究计划代表了一种研究动物中复杂特征套件的遗传学的一种新方法，因此，它将提供可用于在复杂特征中依赖于生物系统的难以开放的难以开放的难以开放的遗传体系变化的方法。这将产生迫切需要的经验数据，以测试对发育和进化的新生，可推广理论的预测。