Allosteric Coordination Complexes

变构配位复合物

• 批准号: 0749614
• 负责人: Chad Mirkin
• 金额: $ 45.5万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0749614&HistoricalAwards=false
• 关键词: Allosteric; Coordination; Complexes

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry program supports work by Professor Chad A, Mirkin at Northwestern University to study functional coordination chemistry-based systems. The laboratory is utilizing a synthetic methodology for the preparation of flexible supramolecular complexes known as the Weak-Link Approach (WLA), resulting in structures that allow one to access multiple geometries in situ. Using this coordination-chemistry approach, the laboratory is targeting allosteric and heteroligated systems with unique functions that cannot easily be accessed using alternative strategies based on conventional coordination- or organic chemistry. Through this work, the laboratory will design: (1) novel detection systems with signal amplification capabilities that have true "off-on" capabilities in terms of the allosterically regulated catalytic event; (2) structures with recognition groups that can orient a complex substrate for the regioselective catalytic functionalization of the substrate; and (3) systems that can function in aqueous media (without organic co-solvents. Practical application of many of the amplification systems demonstrated thus far will require the ability for such complexes to function in water. The work will lead to a new class of highly sensitive and selective chemical detection systems for analytes that are hazardous to the environment and new catalysts capable of effecting high value chemical transformations. In addition, postdoctoral associates, graduate students, and undergraduate students trained through this work will gains skills that make them highly competitive in the US chemical industry. An emphasis will be placed on including women and under-represented minorities in the three year effort.

该无机、生物无机和有机金属化学项目奖项支持西北大学 Chad A, Mirkin 教授研究基于功能配位化学的系统的工作。该实验室正在利用一种称为弱连接方法（WLA）的合成方法来制备柔性超分子复合物，从而产生允许人们在原位获得多种几何形状的结构。 利用这种配位化学方法，该实验室的目标是具有独特功能的变构和异质连接系统，而使用基于传统配位或有机化学的替代策略无法轻松获得这些系统。 通过这项工作，实验室将设计：（1）具有信号放大能力的新型检测系统，在变构调节催化事件方面具有真正的“关-开”能力； (2)具有识别基团的结构，可以定向复杂底物以实现底物的区域选择性催化功能化； (3) 可以在水介质中起作用的系统（没有有机共溶剂。迄今为止演示的许多放大系统的实际应用将需要此类复合物能够在水中起作用。这项工作将导致一类新的针对对环境有害的分析物的高灵敏度和选择性化学检测系统以及能够实现高价值化学转化的新型催化剂此外，通过这项工作接受培训的博士后、研究生和本科生将获得使他们具有高度竞争力的技能。在美国化学三年的努力将重点关注女性和代表性不足的少数群体。