CAREER: A fundamental study of biological/inorganic interfaces: Understanding mechanisms for probing biomolecular interactions using nanostructures

职业：生物/无机界面的基础研究：了解使用纳米结构探测生物分子相互作用的机制

• 批准号: 0748912
• 负责人: Regina Ragan
• 金额: $ 59万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0748912&HistoricalAwards=false
• 关键词: CAREER; fundamental; study; biological; inorganic

The Analytical and Surface Chemistry Program of the Division of Chemistry will support the CAREER development plan of Regina Ragan of the Department of Chemical Engineering and Materials Science at the University of California, Irvine on the project titled "A fundamental study of biological/inorganic interfaces: understanding mechanisms for probing biomolecular interactions using nanostructures." This project aims to understand how material interfaces affect device behavior of electronic measurement platforms that measure interactions between biological molecules. Professor Ragan and her students will utilize scanning probe microscopy integrated with fluorescence microscopy to characterize systems with molecular scale resolution. It is expected that the fundamental knowledge gained from these studies will lead to devices with enhanced performance for drug discovery and environmental monitoring. Professor Ragan will also provide advanced analytical training for high school students at a local high school that serves a predominantly Hispanic student body in order to increase and retain the number of students from under represented groups attending UC Irvine in science, engineering and mathematics.

化学系的分析和表面化学计划将支持加利福尼亚大学化学工程与材料科学系的里贾纳·拉根（Regina Ragan）的职业发展计划，欧文分校的伊尔文大学（Irvine）的项目，名为“生物/无机接口的基本研究：了解使用纳米结构的生物分支相互作用的生物分子相互作用的机制。” 该项目旨在了解材料界面如何影响测量生物分子之间相互作用的电子测量平台的设备行为。 拉根教授和她的学生将利用与荧光显微镜集成的扫描探针显微镜来表征分子尺度分辨率的系统。 预计从这些研究中获得的基本知识将导致具有提高药物发现和环境监测性能的设备。 Ragan教授还将为当地一所高中的高中学生提供高级分析培训，该高中主要为西班牙裔学生团体提供服务，以增加和保留来自代表的群组的学生人数，参加了科学，工程和数学科学，工程和数学。