I-Corps: High-sensitivity, optical, universal nanodetection system

I-Corps：高灵敏度、光学、通用纳米检测系统

• 批准号: 1449745
• 负责人: Regina Ragan
• 金额: $ 5万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1449745&HistoricalAwards=false
• 关键词: Corps; sensitivity; optical; universal; nanodetection

In the sector of medical diagnostic, there is an emerging set of data showing that volatile metabolites provide a signature of infectious and disease states. For instance, biomarkers for cystic fibrosis have been found in patients? saliva and lung cancer biomarkers have been found in a patient's breath. A facile method with trace detection limits would benefit not only diagnosis but also point-of-care evaluations. In the automotive industry, there is concern with detection limit and quantitative real time monitoring of nitrous oxide. To address these challenges, this team proposes the surface enhanced Raman scattering (SERS) sensors that are low-cost, scalable to large areas, with low detection limits.An innovative method has been developed for fabricating self-organized clusters of metal nanoparticles on diblock copolymer thin films as surface enhanced Raman scattering (SERS)-active structures. Sensors based on SERS provide a molecular fingerprint of molecules near the surface though issues of reproducibility and cost have limited technological impact. The developed method reproducibly produces size controlled nanoparticle clusters with nanometer scale inter-particle spacing and represents a significant advancement in scaling, cost and point-to-point reproducibility in sensor performance. The team has theoretically and experimentally identified key geometric properties desirable for performance as optical sensors.

在医学诊断领域，有一组新兴的数据表明，挥发性代谢物提供了传染和疾病状态的签名。例如，在患者中发现了用于囊性纤维化的生物标志物吗？在患者的呼吸中发现唾液和肺癌生物标志物。具有痕量检测极限的便利方法不仅有益于诊断，而且会受益于护理点评估。在汽车行业中，人们关注检测极限和对一氧化二氮的定量实时监测。 To address these challenges, this team proposes the surface enhanced Raman scattering (SERS) sensors that are low-cost, scalable to large areas, with low detection limits.An innovative method has been developed for fabricating self-organized clusters of metal nanoparticles on diblock copolymer thin films as surface enhanced Raman scattering (SERS)-active structures.基于SER的传感器在表面附近提供了分子的分子指纹，尽管可重复性和成本的问题具有有限的技术影响。 开发的方法可重复地产生具有纳米尺度尺度间距的尺寸控制的纳米颗粒簇，并代表了传感器性能的缩放，成本和点对点可重复性的显着进步。该团队在理论上和实验上确定了作为光学传感器性能的关键几何特性。