CAREER: What is Behind the Worldwide Success of Pseudomonas Syringae Pv. Tomato: a Comparative Evolutionary Genomics investigation

职业生涯：丁香假单胞菌 Pv. 在全球范围内取得成功的背后是什么？

• 批准号: 0746501
• 负责人: Boris Vinatzer
• 金额: $ 108.32万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0746501&HistoricalAwards=false
• 关键词: CAREER; What; Behind; Worldwide; Success

The ability of organisms to adapt to new niches becomes a primary concern to our society when it involves the specialization of pathogens to humans, farm animals or crops. Little is known about how plant pathogens, which were adapted to natural mixed-plant communities in pre-agricultural times, evolved into today's highly aggressive pathogens of crops cultivated in monoculture. To fill this void, this project aims at identifying the molecular evolutionary mechanisms that allow pathogens to specialize to specific plant species and to become more aggressive. The bacterial plant pathogen Pseudomonas syringae pv. tomato (the cause of bacterial speck disease of tomato worldwide) and closely related bacteria, will be the focus of this project. A multidisciplinary approach of comparative evolutionary genomics, population genetics, and microbial genetics will be applied leveraging the latest advances in biological sciences and computer sciences. Research and education will be integrated through the development and teaching of an undergraduate course in 'Microbial Genomics and Forensics' and the creation of internship opportunities for undergraduates in the principal investigator's lab and in the biotechnology industry. It is anticipated that this project will uncover genomic changes that occurred in P. syringae pv. tomato during its evolution since the advent of agriculture and that have led to its current aggressiveness and worldwide distribution. Results from this research are expected to constitute the basis for the development of new hypotheses on the evolution of bacterial pathogens in general and to be instrumental in future breeding and engineering of disease resistant crops. Easy access to obtained results will be provided through a web-accessible database. The research in the principal investigator's lab, the undergraduate course and the collaboration with industry will not only attract students to research and provide advanced training, but also give students of underrepresented groups the opportunity to jump-start their professional careers.

当生物适应新的壁ni的能力涉及对人类，农场动物或农作物的专业化时，它成为我们社会的主要关注点。 关于在农业前的自然混合植物社区中如何发展为当今在单一养殖中种植的农作物的高度侵略性病原体的植物病原体如何了解。 为了填补这一空白，该项目旨在确定允许病原体专门针对特定植物物种并变得更具侵略性的分子进化机制。 细菌植物病原体假单胞菌丁香PV。番茄（全球番茄的细菌斑点病的原因）和密切相关的细菌将成为该项目的重点。 比较进化基因组学，种群遗传学和微生物遗传学的多学科方法将利用生物科学和计算机科学方面的最新进展。 研究和教育将通过“微生物基因组学和法医学”的本科课程的发展和教学以及在主要研究者实验室和生物技术行业中为大学生创造实习机会的发展和教学。 预计该项目将发现丁香假单胞菌PV中发生的基因组变化。番茄在农业出现以来的发展中，这导致了当前的侵略性和全球分布。 这项研究的结果预计将构成开发有关细菌病原体演变的新假设的基础，并在抗病作物的未来繁殖和工程中发挥作用。 轻松访问获得的结果将通过可访问的数据库提供。 在首席研究员实验室，本科课程和与行业的合作中的研究不仅会吸引学生进行研究和提供高级培训，而且还使人数不足的团体的学生有机会跳动他们的职业职业。