Genetic basis of morphological diversity and parallel evolution in ninespine sticklebacks

九刺棘鱼形态多样性和平行进化的遗传基础

• 批准号: 0744974
• 负责人: Michael Shapiro
• 金额: $ 42.8万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0744974&HistoricalAwards=false
• 关键词: Genetic; basis; morphological; diversity; parallel

Michael D. Shapiro IOS-0744974 Genetic basis of morphological diversity and parallel evolution in ninespine sticklebacksA major goal of this project is to identify the genetic factors underlying skeletal changes in natural populations of ninespine stickleback fish (Pungitius pungitius). Throughout their Northern Hemisphere-wide range, several exceptional populations of these fish fail to develop the pelvic fin and its supporting bones, a part of the skeleton that is the developmental equivalent of the hindlimbs of humans and other land vertebrates. A principal aim and expected outcome of this work is to identify the genetic basis of pelvic loss in ninespine sticklebacks. Preliminary genetic studies suggest that a single chromosome region has a major influence on pelvic loss in an Alaskan population of these fish; this approach will be extended to identify the gene(s) involved. Another major aim of this project is to examine whether the same or different genes control pelvic reduction in another, geographically distant population of ninespine sticklebacks. This aim will show whether the same or different mechanisms control similar skeletal changes in independent populations. This comparative genetic approach provides a unique opportunity to test whether there are general rules for the types of genetic changes that govern morphology in different groups of organisms.This work will have a broader impact on the scientific community by developing new molecular genetic tools and reagents that can be used by other researchers. Furthermore, the investigator has a strong record of promoting the participation of women in scientific research at the undergraduate, graduate student, and postdoctoral levels. This project will foster the intellectual and career development of a gender group that is traditionally underrepresented in scientific research.

Michael D. Shapiro ios-0744974这个项目的Ninespine Sticklebacksa中形态学多样性和平行演化的遗传基础是该项目的主要目标是确定尼尼匹尼粘粘带鱼（Pungitius Pungitius）自然种群骨骼变化的遗传因素（Pungitius）。在整个北半球整个范围内，这些鱼类的几个特殊种群都无法发展骨盆鳍及其支撑骨骼，这是骨骼的一部分，这与人类和其他陆地脊椎动物的后肢相当。这项工作的主要目的和预期的结果是确定尼诺骨粘性中骨盆损失的遗传基础。初步遗传研究表明，单个染色体区域对这些鱼类的阿拉斯加人口中的骨盆损失有重大影响。该方法将扩展以识别所涉及的基因。该项目的另一个主要目的是检查相同或不同的基因是否控制着另一个地理位置较远的尼波氏症粘性的骨盆减少。该目标将显示相同或不同的机制控制独立人群中的相似骨骼变化。这种比较遗传学方法提供了一个独特的机会，可以测试是否有针对不同生物体形态的遗传变化类型的一般规则。这项工作将通过开发其他研究人员可以使用的新分子遗传工具和试剂对科学界产生更广泛的影响。此外，研究人员在促进妇女参与科学研究的本科生，研究生和博士后水平方面具有良好的记录。该项目将促进一个性别群体的智力和职业发展，该群体传统上在科学研究中的人数不足。