Collaborative Research: AFTOL: Resolving the Evolutionary History of the Fungi

合作研究：AFTOL：解析真菌的进化史

• 批准号: 0732984
• 负责人: Francois Lutzoni
• 金额: $ 95.05万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0732984&HistoricalAwards=false
• 关键词: Collaborative; Research; AFTOL; Resolving; Evolutionary

This project will support a team of investigators who seek to resolve evolutionary relationships within the fungi. The research will enhance understanding of the ancient evolutionary diversification of the fungi by addressing evolutionary relationships among the major groups of fungi. This study will develop integrated molecular and morphological datasets, which will be freely accessible on the Web. Molecular data will include sequences from a target set of 76 genes that were identified from analyses of known fungal genomes. Morphological data will include characters associated with nuclear and cellular division and the morphological organization of hyphae. In addition the study will develop ontologies for morphological characters to promote further sampling and analytical integration across disparate organisms. Fungi make up one of the major groups of life, with an estimated diversity of approximately 1.5 million species. These organisms play crucial ecological roles as decomposers, beneficial mutualists, and parasites and pathogens, including pathogens of humans. The economic significance of fungi is almost incalculable as they perform essential ecological functions and impact diverse applied disciplines, including agriculture, medicine, and drug discovery. A better understanding of the early evolutionary history of the Fungi is necessary to expand our knowledge of the history of life of Earth and the evolution of its ecosystems. Phylogenomic analyses and databases for fungi will transform the field of comparative fungal biology and will benefit all fields of fungal biology that rely on an accurate understanding of evolutionary relationships and diversity of Fungi. The bioinformatics tools for managing and analyzing phylogenomic data that will be developed will be broadly applicable across the Tree of Life. Training and outreach activities will include graduate and post-doctoral training, undergraduate training, and outreach to K-12 educators.

该项目将支持一组研究人员寻求解决真菌内部的进化关系。 该研究将通过解决主要真菌类群之间的进化关系来增强对真菌古代进化多样性的理解。这项研究将开发综合的分子和形态学数据集，这些数据集可以在网络上免费访问。分子数据将包括从已知真菌基因组分析中鉴定出的 76 个目标基因组的序列。形态学数据将包括与核和细胞分裂以及菌丝形态组织相关的特征。此外，该研究还将开发形态特征的本体论，以促进不同生物体的进一步采样和分析整合。 真菌是主要的生命类群之一，估计有大约 150 万种物种。这些生物体作为分解者、有益的共生者、寄生虫和病原体（包括人类的病原体）发挥着至关重要的生态作用。真菌的经济意义几乎是无法估量的，因为它们发挥着重要的生态功能，并影响着不同的应用学科，包括农业、医学和药物发现。更好地了解真菌的早期进化史对于扩大我们对地球生命史及其生态系统进化的了解是必要的。真菌的系统基因组分析和数据库将改变比较真菌生物学领域，并将有利于依赖对真菌进化关系和多样性的准确理解的真菌生物学的所有领域。 将开发的用于管理和分析系统发育数据的生物信息学工具将广泛适用于整个生命之树。 培训和推广活动将包括研究生和博士后培训、本科生培训以及对 K-12 教育工作者的推广。