Collaborative Research: AFTOL: Resolving the Evolutionary History of the Fungi

合作研究：AFTOL：解析真菌的进化史

• 批准号: 0732984
• 负责人: Francois Lutzoni
• 金额: $ 95.05万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0732984&HistoricalAwards=false
• 关键词: Collaborative; Research; AFTOL; Resolving; Evolutionary

This project will support a team of investigators who seek to resolve evolutionary relationships within the fungi. The research will enhance understanding of the ancient evolutionary diversification of the fungi by addressing evolutionary relationships among the major groups of fungi. This study will develop integrated molecular and morphological datasets, which will be freely accessible on the Web. Molecular data will include sequences from a target set of 76 genes that were identified from analyses of known fungal genomes. Morphological data will include characters associated with nuclear and cellular division and the morphological organization of hyphae. In addition the study will develop ontologies for morphological characters to promote further sampling and analytical integration across disparate organisms. Fungi make up one of the major groups of life, with an estimated diversity of approximately 1.5 million species. These organisms play crucial ecological roles as decomposers, beneficial mutualists, and parasites and pathogens, including pathogens of humans. The economic significance of fungi is almost incalculable as they perform essential ecological functions and impact diverse applied disciplines, including agriculture, medicine, and drug discovery. A better understanding of the early evolutionary history of the Fungi is necessary to expand our knowledge of the history of life of Earth and the evolution of its ecosystems. Phylogenomic analyses and databases for fungi will transform the field of comparative fungal biology and will benefit all fields of fungal biology that rely on an accurate understanding of evolutionary relationships and diversity of Fungi. The bioinformatics tools for managing and analyzing phylogenomic data that will be developed will be broadly applicable across the Tree of Life. Training and outreach activities will include graduate and post-doctoral training, undergraduate training, and outreach to K-12 educators.

该项目将支持一个寻求解决真菌中进化关系的调查人员团队。 这项研究将通过解决主要真菌群体之间的进化关系来增强对真菌的古老进化多样性的理解。这项研究将开发综合的分子和形态数据集，在网络上可以自由访问。分子数据将包括从已知真菌基因组分析中鉴定出的76个基因的目标集的序列。形态学数据将包括与核和细胞分裂有关的特征以及菌丝的形态组织。此外，该研究将开发形态学特征的本体论，以促进跨不同生物的进一步采样和分析整合。 真菌构成了生活的主要群体之一，估计多样性约为150万种。这些生物作为分解剂，有益的共同主义者以及包括人类病原体的寄生虫和病原体的生态作用至关重要。真菌的经济意义几乎是无法估量的，因为它们执行基本的生态功能并影响各种应用学科，包括农业，医学和药物发现。对真菌的早期进化史有更好的了解对于扩大我们对地球生命史及其生态系统发展的了解是必要的。真菌的系统基因分析和数据库将改变比较真菌生物学的领域，并将使所有依赖对进化关系和真菌多样性的真菌生物学领域受益。 用于管理和分析将要开发的系统基因数据的生物信息学工具将在整个生命之树中广泛适用。 培训和外展活动将包括研究生和博士后培训，本科培训以及向K-12教育者提供宣传。