Synthesis and Investigation of New Core-Shell Nanoparticles as Molecular Carrier Systems

新型核壳纳米粒子作为分子载体系统的合成与研究

• 批准号: 0723497
• 负责人: Zhibin Guan
• 金额: $ 33万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0723497&HistoricalAwards=false
• 关键词: Synthesis; Investigation; New; Core; Shell

The objective of this joint proposal is to develop efficient syntheses for new dendritic core-shell nanocarriers and to systematically investigate the effects of molecular architecture on their encapsulation and transport of hydrophobic molecules in aqueous systems. By combining the expertise of the Guan group (UC Irvine, USA) for one-pot synthesis of hydrophobic polyolefin cores with controllable topologies and the Haag group (Freie Universitaet Berlin, Germany) for efficient synthesis of hydrophilic and biocompatible polyglycerol shells, the proposed study intends to develop efficient methodology for the synthesis of core-shell nanocarriers and to reveal basic structure-property information on the resulting new amphiphilic molecular architectures. The understanding of structure-property relationships gained from this study will provide critical insight for designing highly efficient molecular nanocarriers that may find potential applications for ink formulation and drug delivery.With this award, the Organic and Macromolecular Chemistry Program and the Office of International Science and Engineering are supporting the research of Professor Zhibin Guan of the Department of Chemistry at the University of California, Irvine. This award coordinates with a collaborative award funded by Deutsche Forschungsgemeinschaft (DFG) for Professor Rainer Haag, Freie Universitaet Berlin, Germany. Professors Guan and Haag's research efforts revolve around the development of facile synthetic methods for the preparation of dendritic polymers. Such chemistry will contribute to environmentally benign methods for polymer synthesis as the method is highly efficient. Successful development of the methodology will have an impact on drug delivery for pharmaceutical industries and on dye encapsulation for chemical industries.

该联合建议的目的是为新的树突状核壳纳米载体开发有效的合成，并系统地研究分子结构对水溶液中疏水分子的包封和运输的影响。通过结合关产品组（UC Irvine，UC，UC IRVINE）的专业知识，以一汤匙合成疏水聚甲基的核心与可控拓扑结合，而Haag组（德国Freie Universitaet，柏林）有效地合成了水生热和生物兼容的ne液，以开发有效的多甘油壳的基本学，以开发有效的多甘油壳。有关新的两亲性分子体系结构的结构质地信息。 从这项研究中获得的对结构核关系关系的理解将为设计高效的分子纳米载体提供关键的见解，这些纳米载体可能会发现墨水配方和药物输送的潜在应用。该奖项，有机和大分子分子化学计划和国际科学和工程办公室正在支持California of California of California的Zhibin Guan Quan Guan Quan usector Zhibin Guan教授的研究。 该奖项与德国弗里伊·哈格（Rainer Haag）教授，德国弗雷伊·哈格（Rainer Haag）教授，德国弗雷伊·哈格（Rainer Haag）教授，由德意志·福申（Deutsche Forschungsgemeinschaft）（DFG）协作协调。 Guan和Haag教授的研究工作围绕着准备树突聚合物的便利合成方法的发展。 这种化学将有助于环境良性的聚合物合成方法，因为该方法高效。 该方法的成功开发将对制药行业的药物输送以及化学工业的染料封装产生影响。