Nanoengineered, Manufacturable, Ion-Implantation Seeded Silica Nanowires for Sensitive BioScreening

用于灵敏生物筛选的纳米工程、可制造、离子注入二氧化硅纳米线

• 批准号: 0700659
• 负责人: Shekhar Bhansali
• 金额: --
• 依托单位: University of South Florida
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0700659&HistoricalAwards=false
• 关键词: Nanoengineered; Manufacturable; Ion; Implantation; Seeded

The goal of this research is to develop a cost effective, robust, reproducible, stable SERS (Surface Enhanced Raman Spectroscopy) substrate with high spatial resolution for ultra-sensitive biodiagnostics. SERS is a powerful, versatile bioscreening technique based on molecular vibrations that currently lacks a tunable, homogenous, repeatable, inexpensive and sensitive substrate of uniform geometry. The central focus of this research is to address the existing SERS challenge through the development of a robust, mass manufacturable, ultra dense, reproducible ordered array of ion implantation seeded silica nanowires of well defined geometry as an effective SERS substrate. The research objectives of the proposal are to (a) investigate and study the growth kinetics of ion-implantation seeded selective nucleation of silica nanowires, (b) synthesize ultra-dense massively parallel array of vertically aligned wires of controlled geometry, (c) develop and apply robust, dynamic nanomanufacturing schemes to achieve reliable and reproducible fabrication of these batch fabricated nanowires, (d) validate the spatially confined SERS substrate for active bioscreening by real-time detection of the desired species and (e) develop a strong interdisciplinary, laboratory-based research, education and outreach program focusing on integration of biology, nanomanufacturing, and microsystems that will have an impact on the training of middle school, high school, community college students and teaching fraternity from all backgrounds.Intellectual Merit: The research opens the gateway for using ion implantation as a general purpose nanoscale catalysis tool towards mass manufacturing bottom-up controlled nanosystems for wide variety of applications. Broader Impact: Advancements in the field of nanoscale science, tools and techniques with emphasis on emerging disciplines like nanomanufacturing would be widely disseminated through the innovative "K- PhD" program. Moreover, the research has participation of the underrepresented groups (minority, women) and fosters partnerships through ongoing international collaboration and exchange. The results of the research will translate into case studies in course modules and seminars/presentations rendered by the investigators.

这项研究的目的是开发一种具有高空间分辨率的具有成本效益，健壮，可重复的，稳定的SER（表面增强的拉曼光谱）底物，用于超敏感的生物诊断。 SERS是一种基于分子振动的强大，多才多艺的生物镜技术，目前缺乏均匀几何形状的可调，同质，可重复，廉价和灵敏的底物。这项研究的主要重点是通过开发可靠的，可制造的，可重现的，可再现的有序的离子植入阵列，以良好定义的几何形状作为有效的SERS底物来应对现有的SERS挑战。 The research objectives of the proposal are to (a) investigate and study the growth kinetics of ion-implantation seeded selective nucleation of silica nanowires, (b) synthesize ultra-dense massively parallel array of vertically aligned wires of controlled geometry, (c) develop and apply robust, dynamic nanomanufacturing schemes to achieve reliable and reproducible fabrication of these batch fabricated纳米线，（d）通过实时检测所需物种的实时检测来验证积极的生物统计，并（e）开发出强大的跨学科，基于实验室的研究，教育和外展计划，着重于生物学，纳米制造和微观系统的整合，从而对所有中学，社区学生进行培训，并在社区，高中，高中，高中，高中生的培训。研究为使用离子植入作为通用纳米级催化工具的门户开辟了大规模制造的自下而上的受控纳米系统，以用于广泛的应用。更广泛的影响：纳米级科学领域，工具和技术的进步，重点是纳米制造等新兴学科，将通过创新的“ K-PHD”计划广泛传播。此外，这项研究的参与是代表性不足的群体（少数族裔，妇女），并通过持续的国际合作和交流来促进伙伴关系。研究结果将在研究人员提供的课程模块和研讨会/演讲中转化为案例研究。