NIRT: Targeted Delivery and Microbial Interactions of Polymer-Functionalized Nanoparticles for Groundwater Contaminant Source-Zone Remediation

NIRT：用于地下水污染物源区修复的聚合物功能化纳米颗粒的靶向输送和微生物相互作用

• 批准号: 0608646
• 负责人: Robert Tilton
• 金额: $ 107.5万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0608646&HistoricalAwards=false
• 关键词: NIRT; Targeted; Delivery; Microbial; Interactions

0608646TiltonThis project focuses on developing polymer-coated iron nanoparticles and targeting delivery to the interface of water/non-aqueous phase liquids to provide more efficient remediation of ground-water contaminated by chlorinated organic compounds, in particular trichloroethylene and related compounds. The project will (i) design "block copolymers" that will maximize accumulation of nano-iron particles in the source zone of such contaminated aquifers, (ii) refine polymer design to achieve maximum dechlorination kinetics, and (iii) incorporate microbial interactions. The approach involves innovative combinations of colloidal phenomena, polymer synthesis and transport in porous media, some of which are derived from the area of targeted drug delivery. The broader impacts component of the project is strong. The research has broad societal implications; contamination by TCE of ground-water aquifers that potentially serve as drinking water supplies is an important public health issue. The project has a plan to integrate the research with interdisciplinary educational activities, including a multi-disciplinary course and K-12 outreach activities.

0608646Tilton该项目重点开发聚合物包覆的铁纳米粒子，并以输送到水/非水相液体界面为目标，以更有效地修复被氯化有机化合物（特别是三氯乙烯和相关化合物）污染的地下水。该项目将（i）设计“嵌段共聚物”，以最大限度地增加纳米铁颗粒在此类受污染含水层源区的积累，（ii）完善聚合物设计以实现最大程度的脱氯动力学，以及（iii）纳入微生物相互作用。该方法涉及胶体现象、聚合物合成和多孔介质传输的创新组合，其中一些源自靶向药物输送领域。该项目具有更广泛的影响力。该研究具有广泛的社会影响； TCE 对可能作为饮用水源的地下水含水层的污染是一个重要的公共卫生问题。该项目计划将研究与跨学科教育活动相结合，包括多学科课程和 K-12 外展活动。