CAREER: Arterial Flow Dynamics-Effects of Pulsatility, Compliance and Curvature

职业：动脉血流动力学 - 搏动性、顺应性和曲率的影响

• 批准号: 0547434
• 负责人: Pavlos Vlachos
• 金额: $ 40万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0547434&HistoricalAwards=false
• 关键词: CAREER; Arterial; Flow; Dynamics; Effects

PROPOSAL NO.: CTS-0547434PRINCIPAL INVESTIGATORS: PAVLOS VLACHOSINSTITUTION: VIRGINIA TECHCAREER: Arterial Flow Dynamics-Effects of Pulsatility, Compliance and CurvatureThis research focuses on the experimental in-vitro modeling and analysis of transitional flows in the cardiovascular system by developing, improving and implementing state-of-the-art experimental methods that will be combined to overcome the limitations of conventional approaches. This pioneering effort will significantly advance understanding of cardiovascular flows and in particular flow transition. Implementing a unique combination of experimental tools and integrating the effects of three important cardiovascular parameters, pulsatility, vessel compliance, and curvature, allows the modeling and analysis of their individual effects as well as their complex interactions. Cardiovascular disease has historically been the leading cause of death in the US and accounts for approximately one third of all deaths worldwide. Cardiovascular flows are governed by complex fluid-structure interactions within short, curved, branching, elastic tubes that undergo lateral dynamic motions while interacting with propagating and reflecting pressure waves. Analysis of the fluid dynamics in the cardiovascular system is a topic of paramount importance, because of the relationship among the hemodynamics, the endothelial cell response and the vascular pathology. Moreover, transitional and turbulent flows are intrinsically related to endothelial cell injury and the origin of vascular disease. However, despite many years of research, cardiovascular flows are poorly understood. The goal of the integrated educational component of this grant is to develop a new model for engineering education using research-based learning. This effort will reinvent and reenergize the classroom experience, demonstrate the multidisciplinary character of modern engineering and stimulate the students intellectual growth. Ultimately, the goal is to enhance recruitment and retention for engineers, including members of underrepresented groups, and to motivate the students to commit to a life-long process of learning, advancing engineering and benefiting society. This goal will be accomplished by translating fluid mechanics and biofluids research to engineering education from middle school to undergraduate and graduate level.

提案号：CTS-0547434主要研究员：PAVLOS VLACHOS机构：弗吉尼亚技术事业：动脉血流动力学-搏动性、顺应性和曲率的影响本研究重点是通过开发、改进和实施心血管系统过渡血流的实验体外建模和分析将结合最先进的实验方法来克服局限性的传统方法。这项开创性的努力将显着增进对心血管血流，特别是血流转变的理解。实施实验工具的独特组合并整合三个重要心血管参数（脉动性、血管顺应性和曲率）的影响，可以对它们的单独影响及其复杂的相互作用进行建模和分析。心血管疾病历来是美国的首要死因，约占全球死亡人数的三分之一。心血管血流受短、弯曲、分支、弹性管内复杂的流体结构相互作用控制，这些管在与传播和反射压力波相互作用的同时进行横向动态运动。由于血流动力学、内皮细胞反应和血管病理学之间的关系，心血管系统中的流体动力学分析是一个至关重要的课题。此外，过渡流和湍流与内皮细胞损伤和血管疾病的起源本质上相关。然而，尽管经过多年的研究，人们对心血管血流仍知之甚少。这笔赠款的综合教育部分的目标是利用基于研究的学习开发一种新的工程教育模式。这一努力将重塑和重新激发课堂体验，展示现代工程的多学科特征，并刺激学生的智力成长。最终目标是加强对工程师（包括代表性不足群体成员）的招聘和保留，并激励学生致力于终身学习、推进工程和造福社会。 这一目标将通过将流体力学和生物流体研究转化为从中学到本科和研究生水平的工程教育来实现。