CORE CENTER

核心中心

• 批准号: 7502828
• 负责人: Peter Gordon Barr-Gillespie
• 金额: $ 49.95万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-04 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7502828
• 关键词: CORE; CENTER

DESCRIPTION (provided by applicant): The Research Core Center at the Oregon Health & Science University will support thirteen principal investigators, funded by the NIDCD and other institutes. The group has a strong focus on and a substantial record of accomplishments in the auditory and vestibular sciences; other investigators within the group study additional areas of NIDCD focus, including olfaction and head and neck cancer. The goal of the Core Center is to centralize expertise on bioengineering, imaging, and mouse genetics in order to enhance presently funded research projects and to stimulate collaborations between participating investigators. In order to achieve these goals, continued support of three Core facilities is proposed. The Bioengineering Core (Alfred Nuttall, director) will provide computer hardware and software support, as well as expertise and instrumentation for measurement of hearing acuity in live animals. The Imaging Core (Dennis Trune and Peter Steyger, co-directors) will centralize confocal and electron-microscopic imaging through the existing OHRC infrastructure. The Mouse Core (Peter Gillespie and John Brigande, co-directors) will provide expertise on mouse husbandry and genotyping as well as two centralized services: assembly of transgenic and gene-targeting constructs and in vivo electroporation to deliver foreign genes into the inner ear in utero. By providing services not available through existing grants, this Core facility will enhance research carried out by users and stimulate productive collaborations. Core B Bioengineering Core Director: Alfred L. Nuttall, Ph.D. DESCRIPTION (provided by applicant): The Bioengineering Core will support all P30 investigators and collaborating investigators. The purpose of this Core is to provide engineering and software expertise needed in the projects of the users and to maintain the OHRC sound-exposure and auditory-brainstem-response (ABR) facilities. The P30 engineer will design and build custom electronic and mechanical devices that solve experimental and data acquisition problems. The P30 computer programmer will write computer software (e.g., Lab-View virtual instruments) to address the experimental needs of the users. Projects undertaken by the engineer and programmer will extend the funded work of the Core users and stimulate collaborative studies between users. The P30 staff will help create common databases that would allow sharing of experimental data among users and enable more secure data backup. Core staff also advise faculty on specification and purchase of instrumentation and software.

描述（由申请人提供）：俄勒冈州健康与科学大学的研究核心中心将支持NIDCD和其他机构资助的13名首席研究人员。该小组在听觉和前庭科学中的成就方面非常重视和实质性记录。小组中的其他研究人员研究了NIDCD重点的其他领域，包括嗅觉和头颈癌。核心中心的目的是集中在生物工程，成像和老鼠遗传学方面的专业知识，以增强目前资助的研究项目并刺激参与研究人员之间的合作。为了实现这些目标，提出了三个核心设施的支持。生物工程核心（主任Alfred Nuttall）将提供计算机硬件和软件支持，以及用于测量活动物听力敏锐度的专业知识和仪器。成像核心（Dennis Trune和Peter Steyger，联合导演）将通过现有的OHRC基础架构集中共焦和电子显微镜成像。小鼠核心（彼得·吉莱斯皮（Peter Gillespie）和约翰·布里甘德（John Brigande），联合指导者）将提供有关小鼠饲养和基因分型的专业知识，以及两种集中式服务：转基因和基因靶向构建构建体和体内电穿孔的组装，以将外源基因运送到Utero的内耳中。通过提供现有赠款无法获得的服务，该核心设施将增强用户进行的研究并刺激生产性合作。 核心b 生物工程核心 主任：Alfred L. Nuttall博士 描述（由申请人提供）：生物工程核心将支持所有P30调查人员和合作调查人员。 该核心的目的是在用户的项目中提供所需的工程和软件专业知识，并维护OHRC声音曝光和听觉Brainstem-Response（ABR）设施。 P30工程师将设计和构建定制的电子和机械设备，以解决实验和数据采集问题。 P30计算机程序员将编写计算机软件（例如Lab-View Virtual Instruments）来满足用户的实验需求。 工程师和程序员开展的项目将扩展核心用户的资助工作，并刺激用户之间的协作研究。 P30员工将帮助创建通用数据库，以允许用户之间共享实验数据并启用更安全的数据备份。 核心人员还向教师提供有关仪器和软件的规范和购买的建议。