COLLABORATIVE RESEARCH: Predicting the Effects of Environmental Change and Host Diversity on the Dynamics of Insect-vectored Generalist Pathogens

合作研究：预测环境变化和宿主多样性对昆虫传播的通用病原体动态的影响

• 批准号: 0525641
• 负责人: Charles Mitchell
• 金额: --
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0525641&HistoricalAwards=false
• 关键词: COLLABORATIVE; RESEARCH; Predicting; Effects; Environmental

Interactions between human-induced environmental change and disease dynamics are one of the most pressing and poorly understood issues facing scientists this century. Vector-transmitted pathogens such as West Nile virus, malaria, and dengue fever, all carried by mosquitoes, or soybean mosaic virus and barley yellow dwarf virus carried by aphids are of particular concern as leading causes of emerging human, plant, and animal diseases. This project will develop a general theory of vector-transmitted pathogens and test that theory using as a model system barley yellow dwarf virus, one of the most economically important diseases of grass crops worldwide. The experiments will be carried out in grasslands in California . The project will test how changes in the environment (moisture and nitrogen availability) interact with changes in plant species diversity and composition to alter aphid behavior, thereby controlling pathogen transmission. The general mathematical theory will allow us to predict the effects of human activity on a variety of plant and animal hosts and their pathogens using a single framework. This study is of both scientific and societal significance, particularly as threats from vector transmitted pathogens to both human health and the agricultural economy increase. It will provide a general understanding about the interactions between pathogens, biodiversity, and community structure.

人类引起的环境变化与疾病动态之间的相互作用是本世纪科学家面临的最紧迫且知之甚少的问题之一。 媒介传播的病原体，如西尼罗河病毒、疟疾和登革热，均由蚊子携带，或由蚜虫携带的大豆花叶病毒和大麦黄矮病毒，作为新出现的人类、植物和动物疾病的主要原因而受到特别关注。该项目将开发媒介传播病原体的一般理论，并使用大麦黄矮病毒作为模型系统测试该理论，大麦黄矮病毒是全球草作物经济上最重要的疾病之一。实验将在加利福尼亚州的草原上进行。该项目将测试环境的变化（水分和氮的可用性）如何与植物物种多样性和组成的变化相互作用，以改变蚜虫的行为，从而控制病原体传播。通用数学理论将使我们能够使用单一框架来预测人类活动对各种动植物宿主及其病原体的影响。这项研究具有科学和社会意义，特别是在媒介传播病原体对人类健康和农业经济的威胁日益增加的情况下。它将提供对病原体、生物多样性和群落结构之间相互作用的一般了解。