Microbial Genome Sequencing: The Complete Genome Sequence of Teredinibacter Turnerae T7902T (g-proteobacterium), The Cultivable Intracellular Endosymbiont of Wood-Boring Marine Mo

微生物基因组测序：Teredinibacter Turnerae T7902T（g-变形杆菌）的完整基因组序列，可培养的钻木海洋微生物的细胞内内共生体

• 批准号: 0523862
• 负责人: Daniel Distel
• 金额: $ 26.12万
• 依托单位: Ocean Genome Legacy
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0523862&HistoricalAwards=false
• 关键词: Microbial; Genome; Sequencing; Complete; Sequence

While most infectious bacteria are considered to be harmful (pathogenic), some may be beneficial or even essential for host survival (symbiotic). Such is the case with Teredinibacter turnerae, a symbiotic bacterium that infects a specialized organ in the gills of marine shipworms. Shipworms are members of a widespread and highly destructive family of worm-like, wood boring clams, and are the only marine animals known that survive and grow with wood as their sole food source. As a result of this unusual diet, shipworms cause an estimated one billion dollars in damage to ships, fishing equipment and marine structures annually but also provide the principle means by which driftwood (a navigational hazard) is degraded and its components are returned to the food web. The symbiont examined here, T. turnerae, is essential to shipworm survival, providing enzymes needed to degrade wood to supplement their nitrogen-poor diet. The objective of the proposed research is to sequence the complete genome of the symbiont T. turnerae. This will provide important insights into the genetic differences that distinguish these beneficial infectious agents from pathogens and non-infectious bacteria and will improve understanding of the ways in which these bacteria (and similar human and animal pathogens) have evolved to evade the host immune system and to accommodate to the intracellular environment. This sequence will also reveal the complete suite of hydrolytic enzymes used by T. turnerae to degrade plant polysaccharides, some of which may have commercial value in manufacture of biofuels from agricultural and domestic waste, in laundry detergents, and in processing of foods and textiles. Finally, because shipworms cannot survive without their symbionts, knowledge of the genes involved in symbiotic infection may facilitate efforts to control shipworm proliferation and the economic damage they cause.

虽然大多数传染性细菌被认为是有害的（致病性），但有些人可能对宿主存活（共生）有益甚至必不可少。 Teredinibacter Turnerae就是这种情况，这是一种共生细菌，在海洋船虫的g中感染了专门的器官。 船虫是像蠕虫般无聊的蛤s的广泛而高度破坏性的家族的成员，也是唯一已知的海洋动物，他们以木材作为其唯一的食物来源而生存和生长。 由于这种不寻常的饮食，船虫每年对船舶，捕鱼设备和海洋结构的损害估计造成了十亿美元的损害，但也提供了浮木（导航危险）降级并将其组件返回到食品网络的原理手段。这里检查的共生体T. Turnerae对虫虫的生存至关重要，提供降解木材以补充其氮贫困饮食所需的酶。拟议的研究的目的是对共生体T. Turnerae的完整基因组进行测序。 这将提供有关将这些有益的传染剂与病原体和非感染细菌区分开的遗传差异的重要见解，并将改善对这些细菌（以及类似的人类和动物病原体）方式的理解，以逃避宿主免疫系统并适应细胞内环境。该序列还将揭示T. turnerae用来降解植物多糖的完整的水解酶，其中一些可能具有农业和家用废物，洗衣服和食物和纺织品的生物燃料的商业价值。最后，由于没有共生体的船虫无法生存，因此对共生感染所涉及的基因的了解可能有助于控制造船虫的扩散及其造成的经济损害。