NSF-Europe Materials Collaboration: New Functionalized Hybrid Systems for Drug Delivery

NSF-欧洲材料合作：用于药物输送的新型功能化混合系统

• 批准号: 0503006
• 负责人: Michael Sailor
• 金额: $ 37.5万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-15 至 2008-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0503006&HistoricalAwards=false
• 关键词: NSF; Europe; Materials; Collaboration; New

This award from the Solid State Chemistry program in the Division of Materials Research to University of California San Diego is to develop a chemically modified matrix of nanocrystalline porous Si or SiO2 to increase the high surface area and free volume at the nanoscale. Chemistries to cap the pores with noble metals, polymers, proteins, and silica derived from silanols will be studied, with the ultimate goal of developing a matrix for the slow release of drug under appropriate physiological conditions. The high surface area and free volume in porous Si films would allow the loading of a large amount of drug, and different drugs will be incorporated into these microscopic particles of porous Si. Delivering drugs to specified locations in the body at specified rates is an important aspect of effective medical therapies. The proposed work will encompass new methods of trapping molecules into porous nanostructures, and new methods of monitoring the porous nanostructures using the optical properties of the materials. In particular, one-dimensional photonic crystals will be prepared whose spectral signatures can report on the amount or type of drug contained within. This proposal, which was received at NSF in response to Materials World Network solicitation, is for collaborative efforts with European partners Drs. Bernard Coq, Jean-Marie Devoisselle and Frederique Cunin of the CNRS Laboratoire de Materiaux Catalytiques et Catalyse en Chimie Organique in Montpellier, France. The Montpellier lab has played a major role in the development and commercialization of liposome-based drug delivery materials in France. This collaborative program will bring together the drug delivery expertise of the Montpellier group with the nanomaterials design expertise of the UC San Diego research group.The work will provide a highly interdisciplinary education to undergraduate, graduate, and post-doctoral students in the fields of nanotechnology, biotechnology, and pharmaceutical chemistry. Nanomaterials would be developed with this award with more sophisticated functions that could be used to more effectively deliver drugs to patients. The European collaborators of this project at the Montpellier laboratory had played a major role in the development and commercialization of liposome-based drug delivery materials in France. With this award, students will be involved in short-term and long-term exchanges and studies between the San Diego and the Montpellier labs.

固体化学研究计划授予加州大学圣地亚哥分校的固体化学计划的奖项是开发一个化学修改的纳米晶体多孔SI或SIO2的矩阵，以增加纳米级的高表面积和自由体积。 将研究用贵族金属，聚合物，蛋白质和二氧化硅来限制毛孔的化学分布，并研究衍生自硅酚的化学物质，其最终目的是开发一个基质，以缓慢释放在适当的生理条件下药物的缓慢释放。高表面积和多孔SI膜中的游离体积将允许大量药物加载，并且将将不同的药物掺入这些微观SI的微观颗粒中。以指定率将药物运送到人体的指定位置是有效的医疗疗法的重要方面。所提出的工作将涵盖将分子捕获到多孔纳米结构中的新方法，以及使用材料的光学性质监测多孔纳米结构的新方法。 特别是，将准备一维光子晶体，其光谱特征可以报告其中包含的药物的数量或类型。该提案是针对材料世界网络征集而在NSF收到的，是与欧洲合作伙伴DRS的合作努力。 Bernard Coq，Jean-Marie Devoisselle和CNRS Laboratoire de Materiaux Catalytiques et catalyze En Chimie Organique的CNRS Laboratoire的Frederique Cunin。 蒙彼利埃实验室在法国基于脂质体的药物递送材料的开发和商业化中发挥了重要作用。 该协作计划将汇集蒙彼利埃集团的药物交付专业知识，以及圣地亚哥加州大学圣地亚哥分校研究小组的纳米材料设计专业知识。这项工作将为纳米技术，生物技术，生物技术，生物技术，和药物学化学领域的本科，研究生和博士后学生提供高度跨学科的教育。 纳米材料将通过该奖项开发，并具有更复杂的功能，可用于更有效地向患者提供药物。 该项目在蒙彼利埃实验室的欧洲合作者在法国基于脂质体的药物递送材料的开发和商业化中发挥了重要作用。 有了这个奖项，学生将参与圣地亚哥和蒙彼利埃实验室之间的短期和长期交流和研究。