SBIR Phase II: Low Cost, Needleless Drug Injection System

SBIR 二期：低成本、无针药物注射系统

• 批准号: 0450559
• 负责人: James Scherer
• 金额: --
• 依托单位: NOVAWAVE TECHNOLOGIES
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-15 至 2007-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0450559&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Low; Cost

This Small Business Innovation Research (SBIR) Phase II project proposes to develop a cheap and novel needleless injector (NI) that uses a ceramic-based electrokinetic pumping mechanism together with suitable nozzle arrays. The Phase II effort will focus on building numerous prototype pump / nozzle systems and determining the ability to achieve performance adequate for subcutaneous and intramuscular injections. Models for predicting the temporal response of the pump / nozzle systems will also be refined and compared to experimental results.The commercial application of this project will be for delivering therapeutics such as vaccines and drugs for both human and veterinary markets. The ability to precisely control the injection temporal profile with the proposed device will enable injection site pain and trauma to be significantly reduced, thereby increasing effectiveness of NI drug delivery as well as reducing the probability of cross - contamination.

这项小型企业创新研究（SBIR）II期项目提议开发一种廉价且新颖的无针喷射器（NI），该喷油器（NI）使用基于陶瓷的电动泵送机制以及合适的喷嘴阵列。第二阶段的工作将集中于构建众多原型泵 /喷嘴系统，并确定实现适合皮下和肌肉内注射的性能的能力。预测泵 /喷嘴系统时间响应的模型也将进行完善，并将其与实验结果进行比较。该项目的商业应用将用于为人类和兽医市场提供疫苗和药物等治疗剂。精确控制注射时间轮廓的能力将使注射部位的疼痛和创伤能够显着降低，从而提高NI药物输送的有效性，并降低交叉污染的可能性。