Bioerodible Matrices for Bone Tissue Engineering

用于骨组织工程的生物可蚀基质

• 批准号: 0336736
• 负责人: Cato Laurencin
• 金额: $ 39.6万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-15 至 2006-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0336736&HistoricalAwards=false
• 关键词: Bioerodible; Matrices; Bone; Tissue; Engineering

0201923LaurencinThis research effort is aimed at developing useful biomimetic constructs for bone while furthering our fundamental understanding of factors important in determining the success of these designs. A multidisciplinary tissue engineering approach is to be followed using principles from chemical, mechanical, and materials engineering as well as cell and molecular biology. The development of constructs of this sort is expected to have clinical applications in grafting of non-unions, surgical arthrodeses, cranio-facial defects, and prosthetic implants and/or implant coatings.This research project builds on the knowledge produced during a series of research projects directed by the Principal Investigator dating from 1990. This new project seeks to design, develop and optimize three-dimensional matrices for use in bone repair. The first aim is to explore the development of new polymer-ceramic constructs fabricated by direct synthesis and incorporation of amorphous calcium phosphate into microspheres used to form the matrix, as well as optimize physicochemical parameters surrounding these new composite microspheres. In the second aim, the delivery of growth factors will also be studied further, building on the previous work by incorporating proteins and factors into the matrix that may enhance cellular endothelialization and bone growth. Finally, in the third aim, extensive in vivo studies will be performed utilizing the constructs designed from aims 1 and 2, paying careful attention to the mechanical strength of the healing defect and the short- and long-term histology and histomorphometry of the defect site.From a basic science standpoint, studies under this work have provided and will continue to provide a better understanding of polymer and ceramic chemistry as it relates to cellular response, matrix fabrication, and ultimate matrix performance (both in vitro and in vivo). In addition to furthering our basic science knowledge, the development of matrices for bone tissue engineering may lead to graft materials for healing bony defects, and thus provide direct benefits to society. As one of only a handful of underrepresented minority principal investigators in bioengineering in America, the Principal Investigator is committed to encouraging the academic growth of younger minority undergraduate and graduate students currently so underrepresented in science.

0201923 Laurencinthis这项研究工作旨在为骨骼开发有用的仿生构建体，同时进一步发展我们对确定这些设计成功重要因素的基本理解。使用化学，机械和材料工程以及细胞和分子生物学的原理，将采用多学科组织工程方法。这种结构的发展预计将在非工会，手术性关节炎，颅骨缺陷以及假体植入物和/或植入涂料的植入方面具有临床应用。这项研究项目以1990年的主要研究人员为指导的一系列研究项目中的一系列研究项目中的一系列研究项目建立了该研究，以设计为新的项目，以设计为brouns new new trone。设计三分。第一个目的是探索通过直接合成和将无定形磷酸钙掺入用于形成基质的微球中的新聚合物陶瓷构建体的发展，并优化了围绕这些新复合微球的物理化学参数。在第二个目标中，还将进一步研究生长因子的传递，这是通过将蛋白质和因子纳入基质中，以增强细胞内皮化和骨骼生长的基础。 Finally, in the third aim, extensive in vivo studies will be performed utilizing the constructs designed from aims 1 and 2, paying careful attention to the mechanical strength of the healing defect and the short- and long-term histology and histomorphometry of the defect site.From a basic science standpoint, studies under this work have provided and will continue to provide a better understanding of polymer and ceramic chemistry as it relates to cellular response, matrix fabrication, and最终矩阵性能（体外和体内）。 除了进一步发展我们的基础科学知识外，骨组织工程矩阵的发展还可能导致疗法骨质缺陷的移植物材料，从而为社会提供直接利益。作为美国生物工程的少数几个人数不足的少数少数少数少数族裔研究人员，主要研究人员致力于鼓励年轻的少数族裔本科生和研究生的学术增长，目前在科学领域的人数少。