EFRI BioFlex: Electrically Mediated Complex Tissue Regeneration

EFRI BioFlex：电介导的复杂组织再生

• 批准号: 1332329
• 负责人: Cato Laurencin
• 金额: $ 200万
• 依托单位: University of Connecticut Health Center
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1332329&HistoricalAwards=false
• 关键词: EFRI; BioFlex; Electrically; Mediated; Complex

The proposal focuses on the creation of novel, electrically-stimulated, bioresorbable electrospun polymeric scaffolds capable of accelerating regeneration of musculoskeletal tissue, with a focus on rotator cuff healing. Tissue engineering has been applied to individual tissues like bone, ligament, tendon, cartilage, muscle, nerve, and blood vessels with a degree of success in the clinical realm. The complex task of full limb regeneration has been left to developmental biologists often studying invertebrates capable of self-regeneration. Lessons learned from scaffold-based tissue engineering can, when blended with developmental and stem cell-based biology and electrical engineering, be applied to the regeneration of complex organs and tissues. This construct will be structured and fine-tuned based on polyphosphazene chemistry, fiber size, and fiber orientation to create an electrically conductive scaffold that exhibits region-specific mechanical properties that mimic those seen in a native muscle-tendon interface. The system will be tested in a rabbit model in which the subscapularis tendon will be transected from the bone with or without transecting the subscapular nerve.

该提案的重点是创建新型，电刺激的，可生物吸收的电纺多聚合物支架，能够加速肌肉骨骼组织的再生，重点是肩袖愈合。组织工程已应用于骨骼，韧带，肌腱，软骨，肌肉，神经和血管等单个组织，并在临床领域取得了一定程度的成功。全肢再生的复杂任务已留给发展的生物学家，经常研究能够自我再生的无脊椎动物。从基于脚手架的组织工程中学到的经验教训可以与发育和干细胞的生物学以及电气工程混合在一起，可应用于复杂器官和组织的再生。该构建体将基于多磷酸化学，纤维尺寸和纤维取向进行结构化和微调，以创建一个可导电支架，该支架具有特定区域的机械性能，这些特性模仿了天然肌肉 - 刺激界面中看到的机械性能。该系统将在兔模型中进行测试，其中capularis肌腱将从骨骼中转移或不带有肩cap骨神经。