MRI: Acquisition of a Liquid Chromatograph-Ion Trap Mass Spectrometer with Electrospray/Atmospheric Pressure Chemical Ionization to Support Faculty-Student Research

MRI：购买具有电喷雾/大气压化学电离功能的液相色谱-离子阱质谱仪，以支持师生研究

• 批准号: 0320738
• 负责人: Paul Jackson
• 金额: $ 20.2万
• 依托单位: Saint Olaf College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0320738&HistoricalAwards=false
• 关键词: MRI; Acquisition; Liquid; Chromatograph; Ion

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Saint Olaf College will acquire a liquid chromatograph-ion trap mass spectrometer (LC/MS) with electrospray/atmospheric pressure chemical ionization. This equipment will enhance research in a number of areas including a) studies on the abundance and structural forms of therapeutic agents, metabolites, personal care products and their degradation products in surface water systems located in agricultural areas; and b) analytical methods development combined with biochemical combinatorial synthesis with a goal towards understanding how an array of chemical structures influence receptor binding sites. Liquid chromatography with mass spectrometric detection (LC/MS) is an extremely powerful technique used for the separation and analysis of complex mixtures. This instrument will substantially strengthen scientific research at the Saint Olaf College, a primarily undergraduate institution. These studies will have a solid impact in the area of environmental chemistry and biochemistry.

通过主要研究仪器（MRI）计划的奖项，圣奥拉夫学院的化学系将获得带有电喷雾/大气压力化学电离的液相色谱量质谱仪（LC/MS）。该设备将增强许多领域的研究，包括a）有关治疗剂，代谢产物，个人护理产品及其降解产品的丰度和结构形式的研究； b）分析方法的发展与生化联合合成结合，目的是了解一系列化学结构如何影响受体结合位点。 具有质谱检测（LC/MS）的液相色谱法是一种非常强大的技术，用于分离和分析复杂混合物。该工具将大大加强主要是本科机构圣奥拉夫学院的科学研究。 这些研究将对环境化学和生物化学领域产生牢固的影响。