CAREER: A Novel Liquid Crystal System for Capillary Electrophoresis

职业：用于毛细管电泳的新型液晶系统

• 批准号: 0307245
• 负责人: Lisa Holland
• 金额: $ 37.53万
• 依托单位: West Virginia University Research Corporation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-14 至 2007-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0307245&HistoricalAwards=false
• 关键词: CAREER; Novel; Liquid; Crystal; System

Professor Lisa A. Holland of Kent State University is funded by the Analytical and Surface Chemistry CAREER program to study phospholipid bicelles as immobilized partitioning media for electrokinetic capillary chromotography. The work involves the characterization of the bicelle media in detail as a function of temperature, mixed micelle ratios, concentration and composition. Then the sieving capabilities of this material will be optimized for separation of polypeptides, proteins and DNA. The ability of bicelle solutions to incorporate receptor systems based on biotin-avidin chemistry will be utilized. The educational component of this work focuses on the use of distance learning to initiate a research program in separations at Haskell Indian Nations University. The interest is in screening traditional tribal medicines for receptor affinity.

肯特州立大学的 Lisa A. Holland 教授受到分析和表面化学职业计划的资助，研究磷脂 bicelles 作为动电毛细管色谱法的固定分配介质。 这项工作涉及对 bicelle 介质作为温度、混合胶束比率、浓度和成分的函数进行详细表征。 然后该材料的筛分能力将被优化以分离多肽、蛋白质和DNA。 将利用 Bicelle 解决方案结合基于生物素-亲和素化学的受体系统的能力。 这项工作的教育部分重点是利用远程学习在哈斯克尔印第安民族大学启动一项关于离职的研究计划。 我们的兴趣在于筛选传统部落药物的受体亲和力。