U.S.-Argentina Cooperative Research Program: Transcriptional Regulation of the Sodium Pump

美国-阿根廷合作研究项目：钠泵的转录调控

• 批准号: 0305484
• 负责人: David Towle
• 金额: $ 3.92万
• 依托单位: Mount Desert Island Biological Laboratory
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0305484&HistoricalAwards=false
• 关键词: U.S.; Argentina; Cooperative; Research; Program

0305484TowleThis U.S.-Argentina award will support Dr. David W. Towle, Mount Desert Island Laboratory (MDIBL) to work with Dr. Carlos M. Luquet of the University of Buenos Aires in Argentina.This project will consist of a state-of-the-art examination of the sodium pump and its role and regulation during adaptation to salinity change in crabs. They will study the mechanisms by which two species of euryhaline crabs, Carcinus maenas from the North Atlantic and Chasmagnathus granulatus from South America, are able to regulate the osmotic concentration of their hemolymph in a varying estuarine environment. The proposed studies have the opportunity to advance our understanding of the ion transport control in invertebrates with the potential to help fisheries, conservation and aquaculture.Dr. Towle has expertise in genomics and molecular biology, while Dr. Luquet has complementary skills in electrophysiology and experimental biology. This combination of molecular and organismal/physiological approach will bring new relevance and insight into both disciplines.

0305484Towle 这个美国-阿根廷奖项将支持 Mount Desert Island Laboratory (MDIBL) 的 David W. Towle 博士与阿根廷布宜诺斯艾利斯大学的 Carlos M. Luquet 博士合作。该项目将包括一个最先进的项目-钠泵的艺术检查及其在螃蟹适应盐度变化过程中的作用和调节。 他们将研究两种广盐蟹（来自北大西洋的 Carcinus maenas 和来自南美洲的 Chasmagnathus capsulatus）能够在不同的河口环境中调节其血淋巴渗透浓度的机制。 拟议的研究有机会增进我们对无脊椎动物中离子传输控制的理解，并有可能帮助渔业、保护和水产养殖。 Towle 拥有基因组学和分子生物学方面的专业知识，而 Luquet 博士则拥有电生理学和实验生物学方面的互补技能。 分子和有机/生理学方法的结合将为这两个学科带来新的相关性和洞察力。