Silica-Based Hybrid Media for Chromatographic Applications

用于色谱应用的二氧化硅基混合介质

• 批准号: 0138114
• 负责人: Luis Colon
• 金额: $ 41.3万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2005-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0138114&HistoricalAwards=false
• 关键词: Silica; Based; Hybrid; Media; Chromatographic

This award to Professor Luis Colon of the SUNY at Buffalo is supported by the Analytical and Surface Chemistry Program in the Chemistry Division. The proposed investigations are focused on the synthesis and characterization of silica-based organic-inorganic hybrid materials for use in high performance liquid chromatography (HPLC) and capillary electrochromatography (CEC). The silica hybrids will be synthesized by copolymerizing alkoxysilanes with hydrolyzable alkoxide groups. This approach results in the production of chromatographic materials in different formats (i.e., films, monoliths, and particles), some with the potential for stability over a wide pH range. The solution chemistry will be monitored with NMR; the physicochemical characteristics of the organic-inorganic hybrids will be assessed using ESCA, SIMS, FTIR, SEM and/or TEM, microbalance gravimetric analysis, and nitrogen gas adsorption methods. The proposed investigations are directed toward the synthesis and characterization of silica glasses. Different formats of the material will be synthesized, suitable for chemical separations. The different parameters used during the fabrication process will be studied to establish the reaction conditions leading to materials with the best performance. The characteristics and compositions of the synthesized glasses will be assessed using a variety of spectroscopic and physical probes. Fabricated materials such as these have potential applications to the separation and purification of a large number of chemicals, ranging from pharmaceutical to environmental areas. These investigations are part of a long-term research program focused on the development and study of new and improved materials for chemical separations in the liquid phase. The research program mainly involves graduate and undergraduate in executing the experimentation, contributing to the education, development, and training of a new generation of scientists.

该奖项授予纽约州立大学布法罗分校的 Luis Colon 教授，该奖项得到了化学部门分析和表面化学项目的支持。拟议的研究重点是用于高效液相色谱（HPLC）和毛细管电色谱（CEC）的二氧化硅基有机-无机杂化材料的合成和表征。 二氧化硅杂化物将通过烷氧基硅烷与可水解醇盐基团的共聚来合成。这种方法可以生产不同形式的色谱材料（即薄膜、整体材料和颗粒），其中一些材料具有在较宽 pH 范围内保持稳定性的潜力。溶液化学性质将通过 NMR 进行监测；有机-无机杂化物的物理化学特性将使用 ESCA、SIMS、FTIR、SEM 和/或 TEM、微天平重量分析和氮气吸附方法进行评估。 拟议的研究针对石英玻璃的合成和表征。将合成适合化学分离的不同形式的材料。 将研究制造过程中使用的不同参数，以确定产生具有最佳性能的材料的反应条件。 合成玻璃的特性和成分将使用各种光谱和物理探针进行评估。诸如此类的人造材料在从制药到环境领域的大量化学品的分离和纯化方面具有潜在的应用。这些研究是长期研究计划的一部分，重点是开发和研究用于液相化学分离的新型和改进材料。 该研究项目主要让研究生和本科生参与实验，为新一代科学家的教育、发展和培训做出贡献。