SBIR Phase I: Immunoconjugate Luminescent Sensors Based on CdTe/CdS Nanoparticles

SBIR 第一阶段：基于 CdTe/CdS 纳米粒子的免疫共轭发光传感器

• 批准号: 0109778
• 负责人: Wei Chen
• 金额: $ 10万
• 依托单位: NOMADICS, INC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0109778&HistoricalAwards=false
• 关键词: SBIR; Phase; Immunoconjugate; Luminescent; Sensors

This Small Business Innovation Research (SBIR) Phase I project seeks to design a nanoparticle-monoclonal antibody conjugate that is capable of detecting select biological warfare agents including Brucella and Francisella. This novel approach to detection is effective, sensitive, selective, inexpensive and truly portable. The system uses an innovative detection method involving two wavelengths of fluorescence, which further increases selectivity and sensitivity. The sensor mechanism uses a thin film of conjugate that can be exploited in a number of ways for detection of other pathogens of relevance to both military and non-military sectors.The commercial applications of the technology to be developed in this project will be in the area of counter-terrorism and in medical, food, agricultural and related fields where pathogen contamination must be detected.

该小型企业创新研究 (SBIR) 第一阶段项目旨在设计一种纳米颗粒-单克隆抗体缀合物，能够检测包括布鲁氏菌和弗朗西斯氏菌在内的精选生物战剂。这种新颖的检测方法有效、灵敏、选择性强、价格低廉且真正便携。该系统采用涉及两种荧光波长的创新检测方法，进一步提高了选择性和灵敏度。该传感器机制使用共轭薄膜，可以通过多种方式利用该共轭薄膜来检测与军事和非军事部门相关的其他病原体。该项目中开发的技术的商业应用将在反恐领域以及必须检测病原体污染的医疗、食品、农业及相关领域。