GOALI: Experimental and Theoretical Studies on Compaction with Application on Pharmaceutical Powders

目标：药物粉末压实的实验和理论研究

• 批准号: 0100063
• 负责人: Antonios Zavaliangos
• 金额: $ 26.98万
• 依托单位: Drexel University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-15 至 2005-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0100063&HistoricalAwards=false
• 关键词: GOALI; Experimental; Theoretical; Studies; Compaction

CMS-0100063EXPERIMENTAL AND THEORETICAL STUDIES ON COMPACTION WITH APPLICATION ONPHARMACEUTICAL POWDERSAntonios Zavaliangos and Iosif Csaba SinkaGOALI - NSF/CMSIn contrast to the scientific advances in drug design, tablet processing hasbeen dominated by empiricism, and it presents a bottleneck for transition tomarket of new discoveries. In this basic research project, DrexelUniversity and Merck & Co., Inc. aim to develop a science basis for thecompaction of pharmaceutical powders that leads to solid dosages. Specificobjectives of this study are to: (i) establish experimental procedures forcharacterization of pharmaceutical powders under conditions characteristicof industrial operations. (ii) determine experimentally the origin of rateeffects and their influence on the mechanical properties of tablets, (iii)formulate constitutive models that portray accurately the behavior of powdermixtures during compaction, (iv) develop design guidelines that will allowrational decision making in pharmaceutical powder formulation.

CMS-0100063药粉压实应用的实验和理论研究Antonios Zavaliangos 和 Iosif Csaba Sinka 目标 - NSF/CMS 与药物设计的科学进步相反，片剂加工一直以经验主义为主，它为新发现向市场过渡带来了瓶颈。 在这个基础研究项目中，德雷克塞尔大学和默克公司旨在为压实药物粉末以形成固体剂量奠定科学基础。本研究的具体目标是：（i）建立在工业操作特征条件下表征药物粉末的实验程序。 (ii) 通过实验确定速率效应的起源及其对片剂机械性能的影响，(iii) 制定本构模型，准确描述粉末混合物在压实过程中的行为，(iv) 制定设计指南，以便在药物粉末配方中做出合理的决策。